The exon junction complex (EJC) plays a major role in posttranscriptional regulation of mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of the spliced mRNA. The complex is formed by the association of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. The 2.2 ...

Resistance against currently used antitubercular therapeutics increasingly undermines efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) inhibitors have shown nanomolar potency against both drug-susceptible and multidrug-resistant strains of the tubercle bacillus. However, their proposed mode of action is lacking structural evidence. We report here the ...

It is shown that a massless scalar probe reveals a universal near-horizon conformal structure for a wide class of black holes, including the BTZ. The central charge of the corresponding Virasoro algebra contains information about the black hole. With a suitable quantization condition on the central charge, the CFT associated with the black hole in our approach is consistent with the recent obse...

Hawking radiation emanating from a two-dimensional analogue of BTZ black holes is viewed as a tunnelling process. Two dimensional BTZ black holes (AdS(2) included) are treated as dynamical backgrounds in contrast to the standard methodology where the background geometry is fixed when evaluating Hawking radiation. This modification to the geometry gives rise to a nonthermal part in the radiation...

In this paper we obtain the flux of Hawking radiation from Rotating BTZ black holes from gauge and gravitational anomalies point of view. Then we show that the gauge and gravitational anomaly in the BTZ spacetime is cancelled by the total flux of a 2-dimensional blackbody at the Hawking temperature of the spacetime. ∗E-mail: [email protected]

Using ideas from an article of P. Bieliavsky, M. Rooman and Ph. Spindel on BTZ black holes, I construct a family of interesting examples of quasi-Poisson actions as defined by A. Alekseev and Y. Kosmann-Schwarzbach. As an application, I obtain a genuine Poisson structure on SL(2, R) which induces a Poisson structure on a BTZ black hole.

A novel cell-targeting, pH-sensitive polymeric carrier was employed in this study for delivery of the anticancer drug bortezomib (BTZ) to cancer cells. Our strategy is based on facile conjugation of BTZ to catechol-containing polymeric carriers that are designed to be taken up selectively by cancer cells through cell surface receptor-mediated mechanisms. The polymer used as a building block in ...

It is shown that a massless scalar probe reveals a universal near-horizon conformal structure for a wide class of black holes, including the BTZ. The central charge of the corresponding Virasoro algebra contains information about the black hole. With a suitable quantization condition on the central charge, the CFT associated with the black hole in our approach is consistent with the recent obse...

OBJECTIVE To investigate the effects of CAL-101, particularly when combined with bortezomib (BTZ) on mantle cell lymphoma (MCL) cells, and to explore its relative mechanisms. METHODS MTT assay was applied to detect the inhibitory effects of different concentrations of CAL-101. MCL cells were divided into four groups: control group, CAL-101 group, BTZ group, and CAL-101/BTZ group. The expressi...