Up to date, miR-137 has been demonstrated as a tumor suppressor in many kinds of human malignancies. In the present study, we conducted transfection, western blot and RT-PCR to explore the role of miR-137 in the development of human glioblastoma (GBM). Here, we found that miR-137 expression was obviously down-regulated in GBM tissues and cells rather than matched non-tumor tissues and NHA cells...

We sought to analyze the current situation of personnel training and scientific research regarding pharmacy intravenous admixture services (PIVAS), provide evidence-based medical knowledge inform for PIVAS in mainland China. A cross-sectional survey was used examine status training, capabilities, needs, output based from perspective leaders The period March April 2019. total 137 hospitals China...

The rapid growth in the number of users of mobile communications means that many operators must find new ways of increasing the capacity of their networks. Their options include allocating more frequency, introducing frequency-hopping techniques, and adding microcells and adaptive antenna systems. The introduction of new frequency bands at 1800 and 1900 MHz is an example of allocating frequency...

Th is research note describes an interconnection between touristic potential of localities impacted by the First and the Second World War, by focusing on a case study of cemeteries in the North-East of Slovakia. Th e case study proposes to create a Slovak part of the ‘dark tourism thematic trail’ through cemeteries from the First World War that could join the existing Polish part of the trail a...

Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that represses expression of various tumor suppressor genes. In the present study, we identified miR-137 as a potential regulator of CtBP1 expression in melanoma cells. Expression of miR-137 in melanoma cell lines was found to inversely correlate with CtBP1 levels. Target Scan predicted a putative site for miR-137 wit...

________________________________________ Introduction __ ___________________________________ Area covered.__________________________________ Aeromagnetic survey.___________________________ Gravity survey.________________________________ Acknowledgments--.. __1________________________ Geology __ __ ____________ _ Rock units_____________________________________ Carboniferous and older rocks._____...

The molecular mechanisms underlying colorectal cancer (CRC) development remain elusive. In this study, we examined the miRNA and mRNA expressions in the adenoma-carcinoma sequence (ACS), a critical neoplastic progression in CRC development. We found that miR-137 was down-regulated in all adenoma and carcinoma tissues. Low miR-137 levels were correlated negatively with tumor progression and meta...

BACKGROUND/AIMS Demonstrating the molecular mechanisms of human adipose tissue-derived mesenchymal stem cells (hADSCs) differentiation and proliferation could develop hADSCs-based cell therapy. METHODS The microRNA-137 (miR-137) and cell division control protein 42 homolog (CDC42) levels were regulated by oligonucleotides transfection. The adipogenic differentiation was induced for 10 days in...

OBJECTIVE MiR-137 has been reported to serve as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the potential mechanism remains largely unclear. The present study aimed to explore the potential molecular mechanisms by which miR-137 regulated NSCLC. MATERIALS AND METHODS Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to quantify the expressio...