design of selective cyclooxygenase-2 (cox-2) inhibitors is still a challenging task because of active site similarities between cox isoenzymes. to help with this issue, we tried to generate a 3d-qsar (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of cox-2 active sites. compounds in a series of resveratrol derivatives inhibitors with ...

Background and Objectives: Cyclooxygenese-2 (COX-2) expression in breast cancer and its correlation with tumor prognosis is unclear. We investigated the incidence of COX-2 expression in patients and assessed interactions between COX-2 and clinical features of cancer and expression of HER2/neu, estrogen receptor (ER), and progesterone receptor (PR). Methods: COX-2 expression was investigated by...

cyclooxygenase-2 (cox-2) has a pivotal role in the pathogenesis of the lung cancer. it is known that cox-2 negatively regulates the activity of a number of tumor suppressors, including p53. consequently, inhibition of cox-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. in this regard, we investigated the effect of cox-2 signaling blockade on p53 and cox-2 e...

background and objectives: cyclooxygenese-2 (cox-2) expression in breast cancer and its correlation with tumor prognosis is unclear. we investigated the incidence of cox-2 expression in patients and assessed interactions between cox-2 and clinical features of cancer and expression of her2/neu, estrogen receptor (er), and progesterone receptor (pr). methods: cox-2 expression was investigated by...

patients and methods this was a historical cohort study. a total of 1396 patients admitted between march 2011 and march 2012 in 16 mmt clinics (13 private and 3 state clinics) in rafsanjan, entered the study and their retention rate was examined for one year. the patients’ data abstracted from their medical records using checklists and collected by clinics’ staff. data analyses were performed u...

cancer is considered as a challenging deathly disease and discovering or synthesis of new cytotoxic agents is a worldwide attempt. in this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having differesnt cox-1 and/or cox-2 selectivities, have been examined on human hepatocarcinoma (hepg2), lung carcinoma (a549), and breast adenocarcinoma (mcf-7...

original article   extended exposure to noise can cause permanent hearing damage. this study aimed to determine the incidence time of hearing loss and its effective factors in workers exposed to noise. this retrospective cohort study, was conducted on a total of 273 workers in various sectors of kerman copper by-industries co. their hearing status and the incidence of hearing loss (hearing thre...