HP1 proteins are essential components of heterochromatin and contribute to the transcriptional repression of euchromatic genes via the recruitment to specific promoters by corepressor proteins including TIF1 and Rb. The Caenorhabditis elegans HP1 homologue HPL-2 acts in the "synMuv" (synthetic multivulval) pathway, which defines redundant negative regulators of a Ras signaling cascade required ...

OBJECTIVE This study aimed to investigate whether self-rated health status (SRH) and subjective health complaints (SHC) of urban Chinese women are associated with their health-promoting lifestyles (HPL). METHODS We conducted a cross-sectional study on 8142 eligible Chinese participants between 2012 and 2013. Demographic and SHC data were collected. Each subject completed the SRH questionnaire...

Objective: The term Mauve factor (pyrroluria) dates back to 1958 when Dr. Abram Hoffer defined the condition as elevated levels of pyrroles in urine, currently called hydroxyhemepyrrolin-2-one (HPL). It was suggested that raised pyrrole lead depletions zinc and vitamin B6, which, turn, were hypothesized result a range psychiatric disorders, such schizophrenia, anxiety, depression. Treatment imp...

To examine whether pre-β-high-density lipoprotein (HDL) may be involved in regulation of human placental lactogen (hPL) release, pre-β-HDL was isolated from term pregnancy serum, and the effect of purified pre-β-HDL on hPL release from trophoblast cells was examined after 1 h of exposure. Pre-β-HDL stimulated a dose-dependent increase in hPL release with half-maximal stimulation at a dose of 30...

Handwerger, Stuart, Geeta Datta, Brian Richardson, Carrie M. Schmidt, Tariq Siddiqi, Lisa Turzai, and G. M. Anantharamaiah. Pre-b-HDL stimulates placental lactogen release from human trophoblast cells. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E384–E389, 1999.—To examine whether pre-b-high-density lipoprotein (HDL) may be involved in regulation of human placental lactogen (hPL) release, pre-...

Several drugs and natural compounds are known to be highly neurotoxic, triggering epileptic convulsions or seizures, and causing headaches, agitations, as well as other neuronal symptoms. The neurotoxic effects of some of these compounds, including theophylline and ginkgotoxin, have been traced to their inhibitory activity against human pyridoxal kinase (hPL kinase), resulting in deficiency of ...

The inhibition of digestive lipases by the antiobesity drug Orlistat along with lipolysis levels and fecal fat excretion were measured in healthy humans. Orlistat was found to be a powerful gastric lipase inhibitor, achieving 46.6--91.4% enzyme inhibition and thus greatly reducing gastric lipolysis of solid and liquid meals (11--33% of respective controls). Gastric lipase inhibition by Orlistat...

Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that initiates infection by colonising the upper airways. Strategies interfere with this interaction may therefore have clinically significant impact on ability of NTHi to cause disease. We previously shown strains commensal bacterium haemolyticus (Hh) produce novel haem-binding protein, haemophilin, can prevent growth an...

AIM To determine the effect of maternal cigarette smoking on cord blood concentrations of E3, hPL, beta-hCG, FSH, LH, and cortisol. METHODS Hormone concentrations were measured in term neonates of 100 smoking and 100 non-smoking mothers. RESULTS The median E3, hPL, beta-hCG, FSH, LH and cortisol cord blood concentrations in the non-smoking mothers' offspring were 212 ng/mL, 2.00 microg/mL, ...

OBJECTIVES A health-promoting lifestyle (HPL) is a factor that affects the quality of life (QoL) in patients with beta-thalassemia (β-thalassemia). Due to the lack of studies of this issue, this study aimed to determine the association between HPL and QoL among adults with β-thalassemia. METHODS This cross-sectional (descriptive-analytic) study was conducted among 389 adult patients with β-th...