BACKGROUND This study was aimed to assess the effect of endometrial movements on pregnancy achievement in intrauterine insemination (IUI) cycles. MATERIALS AND METHODS The population of this observational study was composed of unexplained infertility couples undergoing first-time IUI with clomiphene citrate between September 2010 and October 2011. Not only endometrial movements, but also thic...

STUDY QUESTION Does intrauterine insemination in the natural cycle lead to better pregnancy rates than intracervical insemination (ICI) in the natural cycle in women undergoing artificial insemination with cryopreserved donor sperm. SUMMARY ANSWER In a large cohort of women undergoing artificial insemination with cryopreserved donor sperm, there was no substantial beneficial effect of IUI in ...

OBJECTIVE To investigate the effect of double versus single intrauterine insemination (IUI) per treatment cycle in women with unexplained infertility. DESIGN Meta-analysis of randomized controlled trials. MAIN OUTCOME MEASURE(S) Clinical pregnancy rates per couple. INTERVENTION(S) Electronic searches of the Cochrane Central Trials Registry and Medline without year and language restriction...

We have examined the potential of follicle-stimulating hormone (FSH) therapy for the male to improve pregnancy rates in intrauterine insemination (IUI) with husband's spermatozoa. A prospective randomized trial was performed in 148 couples undergoing IUI because of male subfertility. In the treatment group, 150 IU FSH were administered to the husbands, either i.m. or s.c., three times a week, s...

BACKGROUND While intrauterine insemination (IUI), a simple, inexpensive and non-invasive technique, is the most used assisted reproduction technology (ART) worldwide, the risk of major birth defects following IUI is paradoxically not well documented. METHODS Retrospective cohort study performed in Burgundy, France, over a 9-year period which consisted of the cross analysis of two prospective ...

OBJECTIVE To determine the optimal infertility therapy for women at the end of their reproductive potential. DESIGN Randomized clinical trial. SETTING Academic medical centers and private infertility center in a state with mandated insurance coverage. PATIENT(S) Couples with ≥ 6 months of unexplained infertility; female partner aged 38-42 years. INTERVENTION(S) Randomized to treatment w...

Objectives. Intrauterine insemination (IUI) is frequently used as a first line strategy in the treatment of male and unexplained infertility. Threshold levels of sperm parameters associated with IUI success are controversial. The aim of this study was to evaluate the influence of sperm parameters on the outcome of IUI. Study Design. A prospective observational study. Patients and methods. This ...

1 This is a revised version of the first chapter of my dissertation and I stand in great debt to my dissertation supervisor Andrew Postlewaite, Stephen Coate, and Stephen Morris for comments, suggestions, encouragement, and patience. Two referees and an associate editor provided detailed comments and criticism that led to significant improvements of the paper. I also thank George Mailath, Andre...