Action potential initiation and propagation requires clustered Na(+) (voltage-gated Na(+) [Nav]) channels at axon initial segments (AIS) and nodes of Ranvier. In addition to ion channels, these domains are characterized by cell adhesion molecules (CAMs; neurofascin-186 [NF-186] and neuron glia-related CAM [NrCAM]), cytoskeletal proteins (ankyrinG and betaIV spectrin), and the extracellular chon...

This major international history project succeeded because of the goodwill, commitment, and collaborative endeavor of a team of researchers drawn not only from different countries but also from different disciplines. Its immediate product is a recently published book, HISCO: Historical International Standard Classification of Occupations (van Leeuwen, Maas, and Miles 2002). The authors describe...

OBJECTIVE Previous studies have identified that kazrin is a constituent of desmosome and influences intercellular adhesion, growing development and morphology. We previously cloned another new isoform, kazrin F and found that it has anti-apoptotic effects on human glioma cell line. To further explore whether kazrin F is involved in tumorigenesis, we investigated its expression and role in cervi...

 S 185 I.  186 II.          186 1. Superoxide-generating NADPH oxidase 186 2. Zinc deficiency potentiates iron-mediated free radical production 189 (a) Iron accumulation in zinc-deficient plants 189 (b) Iron-induced production of free radicals 189 3. Zinc deficiency-enhanced photooxidation 191 (a) Decrease in photosynthesi...

DNA chips have proven to be effective tools in detecting gene expression levels. Compared with DNA chips Abstract using complementary DNA as probes, oligonucleotide microarrays using oligonucleotides as probes have attracted great attention because of their well known advantages. The design of gene-specific probes for each target is essential to the development of oligonucleotide microarrays. W...

Objective: Rhenium is one of the most valuable elements for internal radiotherapy because Re and Re have favorable physical characteristics. However, there are problems when proteins such as antibodies are used as carriers of Re. Labeling methods that use bifunctional chelating agents such as MAG3 require the conjugation of the Re complex to protein after radiolabeling with the bifunctional che...

microRNAs (miRNAs) are known to be important in tumor initiation and progression. Recent studies have demonstrated that miR-186 is critical in several types of cancer, including human non-small cell lung cancer, bladder cancer and pancreatic ductal adenocarcinoma. However, the functions of miR-186 in prostate cancer (PCa) are still unclear. In the present study, downregulation of miR-186 in PCa...