Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation which suggests that tyrosine kinase-specific inhibitors might be used as anticancer agents. When the cytotoxic effect of the potent tyrosine kinase inhibitor genistein on various cell lines was studied, we observed that 9-hydroxyellipticine-resistant Chinese hamster lung cells (DC-3F/9-OH-E) were markedl...

OBJECTIVE Small aortic valve replacement remains a challenging hemodynamic problem. A new bioprosthesis (3F Therapeutics, Lake Forest, Calif) was designed to further improve the hemodynamic performance currently achieved with stentless bioprostheses. This valve consists of a tubular structure assembled from 3 equal sections of equine pericardial material, with virtually no foreign material exce...

The multidrug resistant cell line DC-3F/ADII was obtained by stepwise selection for growth in actinomycin D (ActD). Compared with parental cells, it displays high resistance to ActD and vincristine and low resistance to colchicine and daunorubicin. These cells overexpress a form of P-glycoprotein (Pgp1) containing a double mutation, I837L and N839I, in transmembrane domain (TM) 9; when transfec...

Genotype 3 hepatitis E viruses (HEVs) are distributed across the world and are now considered to be an emerging public health concern in industrialized countries. At least 10 genotype 3 subtypes have been identified in humans and animals worldwide. It was recently reported that the sensitivities of HEV RNA assays differ greatly. We have assessed the influence of genotype 3 diversity on the perf...

هدف: هدف از پژوهش حاضر مقایسۀ واکنش ­پذیری هیجانی و نظریه ذهن کودکان بر اساس سبک ­های ابرازگری مادرانشان بود. روش: روش توصیفی نوع علّی-مقایسه­ ای بود در دو گام به صورت آنلاین انجام رسید. ابتدا با استفاده نمونه ­گیری دسترس، تعداد 105 نفر مادرانی که نمرات آن­ها هر یک پرسشنامه کینگ امونز (1990)، دوسوگرایی (1990) کنترل راجر نشوور (1987) انحراف استاندارد بالاتر میانگین دست آمد (در گروه 35 نفر) دوم وا...

The $2p$-$3s$ lines of Fe XVII in the X-ray spectrum O-type star $\zeta$ Puppis exhibit an anomalous (3G + M2)/(3F) line ratio $\sim$1.4, comparison with $\sim$2.4 for almost all other collisionally excited astrophysical spectra. Based on work Mauche et al. (2001), we conjectured that strong UV field produces observed by depopulation metastable $3s$ states, and can potentially be used as indepe...

Photoionization methods have been used to study the reactions of the molecular ion in vinyl fluoride to yield the ionic products C3H 3F{, C3H 4F+, and C3Ht. Quantitative measurements are reported of the effect of the vibrational state of the reactant ion on the product distribution and overall reaction cross section. Reaction cross sections for all three channels decrease with reactant internal...

Glycoproteins and gangliosides of spontaneously trans formed Chinese hamster lung cells (DC-3F) and of vincristineand daunorubicin-resistant sublines of DC-3F have been com pared. These resistant cells and also actinomycin D-resistant cells have been shown to have reduced permeability to drug and to exhibit some degree of mutual cross-resistance to all three agents. Glycoproteins of tritiated g...