Protease activated receptors (PARs) are G-protein coupled receptors that are activated by an unique proteolytic mechanism. These receptors play crucial roles in hemostasis and thrombosis but also in inflammation and vascular development. PARs have also been implicated in tumor progression, invasion and metastasis. In this study, we investigated expression and signaling of PAR1 in nonmalignant p...

BACKGROUND Within the field of oncology, increasing access to high quality care has been identified as a priority to reduce cancer disparities. Previous research reveals that the facilities where patients receive their cancer care have implications for cancer outcomes. However, there is little understanding of how patients decide where to seek cancer care. This study examined the factors that s...

Recently, the National Cancer Institute (NCI) established criteria for determination of microsatellite instability (MSI) in colorectal tumors. Although the best panel of markers for ovarian tumors is not known, we evaluated epithelial ovarian cancers for MSI based on the NCI recommendations. One hundred and nine ovarian tumors were analyzed for MSI by gel analysis of paired germ-line and tumor ...

Intercellular adhesion molecule-1 (ICAM-1) expression by tumour cells may be involved in their interaction with defensive cells. In this study the surface ICAM-1 expression and soluble ICAM-1 (sICAM-1) production by five small cell lung cancer (SCLC) and five non-SCLC (NSCLC) cell lines was investigated. In addition, the effects of ICAM-1 upregulation by cytokines on the adhesion of lung cancer...

Despite recent improvements in the detection and treatment, prostate cancer continues to be the most common malignancy and the second leading cause of cancer-related mortality in American men. Over the last decade, researchers began looking at MRI as a way of improving the early diagnosis of prostate cancer. This paper reviewed prostate MRI studies at the molecular imaging clinics at National C...

هدف: این پژوهش با هدف ارائه مدل چالش‌های پرورش کودکان کم‌شنوای پیش‌دبستانی از دیدگاه مادران و متخصصان بر اساس نظریه داده‌بنیاد انجام ‌شده است. روش: نمونه 15 مادر کودک کم‌شنوا 4 تا 6 ساله انجمن والدین شهر تهران 5 متخصص حوزه ناشنوا بودند که در سال 1400 استفاده روش نمونه‌گیری هدفمند انتخاب شدند. چالش ­های طریق مصاحبه نیمه ساختاریافته عمیق رسیدن به اشباع نظری جمع‌آوری کدگذاری (کدگذاری باز، محوری ان...

A comparison of detection limits of gas chromatography-mass spectrometry (GC-MS) in selected ion monitoring (SIM) with gas chromatography-tandem mass spectrometry (GC-MS/MS) in selected reaction monitoring (SRM) mode with both electron ionization (EI) and negative-ion chemical ionization (NCI) are presented for over 50 pesticides ranging from organochlorines (OCs), organophosphorus pesticides (...

National Center for Nanoscience and Technology of China; Institute of High Energy Physics, Chinese Academy of Sciences; and National Cancer Institute (NCI), NIH, based at the Embassy of the United States, Beijing, P.R. China; Department of Radiology, Howard University, Washington, District of Columbia; Nanobiology Program, National Cancer Institute, NIH, Frederick, Maryland; Office of the Direc...

OBJECTIVE We used demographic and clinical data to design practical classification models for prediction of neurocognitive impairment (NCI) in people with HIV infection. METHODS The study population comprised 331 HIV-infected patients with available demographic, clinical, and neurocognitive data collected using a comprehensive battery of neuropsychological tests. Classification and regression...