نتایج جستجو برای: تیازین ایزوسیانید h4
تعداد نتایج: 5769 فیلتر نتایج به سال:
Cured meats are desirable to consumers across the world. Unfortunately, use of nitrite obtain cured characteristics has health implications for consumers. Three (3) kg each ham were produced and labeled as H0, H1, H2, H3 H4, respectively. H0 represented traditional with nitrite-curing salt H4 contained common alone. H2 15.0 mg kg-1, 30.0 kg-1 60.0 Ocimum gratissimum leaf extract an additive sal...
The B7 family plays a critical role in both positive and negative regulation of immune responses by engaging a variety of receptors on lymphocytes. Importantly, blocking coinhibitory molecules using antibodies specific for CTLA-4 and PD-1 enhances tumor immunity in a subset of patients. Therefore, it is critical to understand the role of different B7 family members since they may be suitable th...
OBJECTIVE B7-H4, a member of the B7 family of immunoregulatory receptors, may participate in the negative regulation of cell-mediated immunity. Aberrant B7-H4 expression is detected in some tumors and it plays a role in the occurrence and development of tumors. The aim of this study was to elucidate the functional and structural properties of B7-H4. METHODS We developed a monoclonal antibody ...
2- (1-( آمینو متیل) سیکلو هگزیل) استیک اسید (گاباپنتین) یک دارو شیمیایی است که برای درمان تشنج، درد نوروپاتیک، درمان میگرن، اختلال دو قطبی و برای درمان درد نیز استفاده می شود. در این پروژه مشتقات n-سیکلو هگزیل -2- (3-اکسو-2-آزا اسپیرو[5,4] دکان-2-ایل)-2-آریل استامید را با استفاده از گاباپنتین، آلدهیدهای آروماتیک و سیکلو هگزیل ایزو سیانید در حلال اتانول 96% و در حمام آب گرم 50 درجه سلسیوس که از ...
در این پروژه ابتدا یک روش ساده، ارزان، سازگار با محیط زیست و قابل تهیه در مقیاس بالا برای سنتز یک سری از مشتقات 2h-بنزو[b][4،1]-تیازین-3(4h)-اون بر روی آلومینای اسیدی در دمای50 درجه سانتی گراد ارائه شد. این ترکیبات، مواد اولیه بسیاری از تحقیقات و ماده اولیه تهیه برخی ترکیبات فعال بیولوژیک می باشند. در این واکنشها با استفاده از 2-برومو آلکانوات ها و مشتقات 2-آمینو تیوفنل، یک حد واسط غیر حلقوی ب...
We analyzed the relationship between histone acetylation and transcriptional regulation at 40 Saccharomyces cerevisiae promoters that respond to specific activators and repressors. In accord with the general correlation between histone acetylation and transcriptional activity, Gcn4 and the general stress activators (Msn2 and Msn4) cause increased acetylation of histones H3 and H4. Surprisingly,...
The immunological mechanism mediated by T cells is the main therapeutic target in the treatment of renal cell carcinoma (RCC) with interleukin (IL)-2 and interferon (IFN)-α. The aim of the present study was to evaluate the role of B7-H4 in the IL-2, IFN-α and IFN-γ treatment of clear cell RCC (ccRCC). A total of 154 paraffin-embedded ccRCC tissues were studied using immunohistochemistry, which ...
Clopidogrel, a thienopyridine antiplatelet prodrug, is metabolized by oxidation to 2-oxo-clopidogrel, followed by conversion to its pharmacologically active thiol metabolite. After oral administration of clopidogrel to humans, two thiol isomers (H3 andH4) are observed in plasma,with similar concentrations, and only H4 is active in humans. In this work, themechanism of stereoselectivity in the f...
The NuA4 complex is a histone H4/H2A acetyltransferase involved in transcription and DNA repair. While histone acetylation is important in many processes, it has become increasingly clear that additional histone modifications also play a crucial interrelated role. To understand how NuA4 action is regulated, we tested various H4 tail peptides harboring known modifications in HAT assays. While di...
PURPOSE This study was designed to investigate the expression of B7-H4 protein, a member of the B7 family that is involved in the regulation of antigen-specific immune responses, in normal breast and in primary and metastatic breast carcinomas. EXPERIMENTAL DESIGN Archival formalin-fixed tissue blocks from breast cancers and normal somatic tissues were evaluated for B7-H4 expression by immuno...
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