Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues upon elastase-based proteolysis of the exposed reactive center loop (RCL). However, the molecular mechanisms that regulate the RCL proteolysis by co-existing host and bacterial elastases in inflamed/infected tissues remain unknown. We document that RCL-localized Asn(347) glycosylation fine-tunes the RC...

The author proposes a bicultural self theory for contemporary Chinese individuals, encompassing 2 main components: the individual-oriented self and the socialoriented self. The social orientation is rooted in traditional Chinese conceptualization of the self, whereas the individual orientation has evolved and developed under Western influences along with recent societal modernization. The autho...

1. Induction proofs, type I: Sum/product formulas: The most common, and the easiest, application of induction is to prove formulas for sums or products of n terms. All of these proofs follow the same pattern. (a) ∑n i=1 i(i+ 1) = n(n+1)(n+2) 3 (b) ∑n i=0 2 i = 2n+1 − 1 (sum of powers of 2) (c) ∑n i=0 r i = 1−r n+1 1−r (r 6= 1) (sum of finite geometric series) (d) ∑n i=0 i!i = (n+ 1)!− 1. Soluti...

17 Helicobacter pylori VacA is a secreted pore-forming toxin that is comprised of two 18 domains, designated p33 and p55. The p55 domain has an important role in binding of VacA to 19 the cell surface. About 111 residues at the amino-terminus of p55 (residues 312-422) are 20 essential for the intracellular activity of VacA, which suggests that this region may constitute a 21 subdomain with an a...

Helicobacter pylori VacA is a secreted pore-forming toxin that is comprised of two domains, designated p33 and p55. The p55 domain has an important role in the binding of VacA to eukaryotic cell surfaces. A total of 111 residues at the amino terminus of p55 (residues 312 to 422) are essential for the intracellular activity of VacA, which suggests that this region may constitute a subdomain with...