This study investigated the potential biological activities by determining antioxidant (DPPH Assay), antibacterial (Agar-well Diffusion Method), and antiquorum sensing (Crystal Violet based Microtitre Plate Biofilm Assay) of selected wild tea leaves Mt. Province, namely: Cinnamomum mercadoi S. Vidal, Gaultheria leucocarpa var. cumingiana (S.Vidal), Clausena sanki (Perr.) J.F. Molino mollis (Mer...

PerR is a ferric uptake repressor (Fur) homolog that functions as the central regulator of the inducible peroxide stress response in Bacillus subtilis. PerR has been previously demonstrated to regulate the mrgA, katA, ahpCF, hemAXCDBL, and zosA genes. We now demonstrate that PerR also mediates both the repression of its own gene and that of fur. Whereas PerR-mediated repression of most target g...

Prosopis africana (Guill and Perr) Taub fruit methanolic extract was tested for its antinociceptive properties. 4.2% w/w dry yield obtained after 48 hours of 80% methanol at room temperature during cold maceration. occasional shake every two hours. It had a golden brown color, sticky odorous, foamed as it dissolved in distilled water. In mice, the did not exhibit any acute hazardous effects stu...

The Staphylococcus aureus genome encodes three ferric uptake regulator (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of PerR, we inactivated the gene by allelic replacement using a kanamycin cassette, creating strain MJH001 (perR). PerR was found to control transcription of the genes encoding the oxidative stress resistance proteins catalase (KatA), alkyl hydroperoxide reduc...

We have characterized group A Streptococcus (GAS) genome-wide responses to hydrogen peroxide and assessed the role of the peroxide response regulator (PerR) in GAS under oxidative stress. Comparison of transcriptome changes elicited by peroxide in wild-type bacteria with those in a perR deletion mutant showed that 76 out of 237 peroxide-regulated genes are PerR dependent. Unlike the PerR-mediat...

This research aimed to investigate the phytoconstituents and antibacterial effects of methanol ethyl acetate stem bark extracts Detarium microcarpum (DM). The phytochemicals were detected quantified while activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi was established determining zone inhibition (ZI), minimum inhibitory concentration (MIC), bactericidal (MBC). Phytoch...