OBJECTIVE To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC). MATERIALS AND METHODS Male Swiss mice (20-30g) were pretreated with rhIL-11 (25-625 mg, subcutaneously.) 30 min before intraperitoneal injection of IFS (400 mg/kg) or with saline (control group). Twelve hours later, HC was evaluated ...

PURPOSE The purpose of this research was to identify promiscuous T-helper cell determinants (THd) from carcinoembryonic antigen (CEA) to be used to prime T-cell help for cancer therapy. CEA was selected because this antigen is expressed in an important variety of carcinomas. EXPERIMENTAL DESIGN Potential promiscuous THd from CEA were predicted using available computer algorithms. Predicted pe...

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In 1985 Brinster et al. [1] observed that linearized DNA injected in the cytoplasm of mouse zygotes underwent spontaneous supercoiling within 24 h. This finding suggests that DNA prefers and functions best in tertiary structure. In an effort to improve the efficiency of transgenesis by cytoplasmic injection, DNA was condensed with MgCl2 to form a three dimensional rod-shaped DNA prior to inject...

INCONEL@ alloy 625 is a nickel-chromium-molybdenum alloy that is used for its high strength, excellent fabricability and weldability, and outstanding corrosion resistance. The outstanding and versatile corrosion resistance of INCONEL alloy 625 under a wide range of temperatures and corrosive environments is the primary reason for its wide acceptance in chemical processing and other applications...