The expression of acute experimental autoimmune encephalomyelitis (EAE) in mice is controlled by several dominant genes, H-2 and histamine sensitization genes. SJL/J and SWR/J, which are H-2s and H-2q, respectively, are susceptible to EAE and sensitive to Bordetella pertussis histamine-sensitizing factor (HSF), which produces a vasoactive amine hypersensitivity. Other H-2s or H-2q strains such ...

Axonal damage is a major morphological alteration in the CNS of patients with multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the underlying mechanism for the axonal damage associated with MS/EAE and its contribution to the clinical symptoms remain unclear. The expression of a fusion protein, named "Wallerian degeneration slow" (Wld(S)), c...

It has been reported that the spinal cord possesses Gonadotropin-releasing hormone (GnRH) receptor and that GnRH has neurotrophic properties. Experimental autoimmune encephalomyelitis (EAE) causes neurodegeneration in spinal cord. Thus, the present study was designed to determine whether administration of GnRH reduces the severity of EAE. The clinical signs of locomotion, axonal morphometry and...

Multiple sclerosis (MS) is a complex multifactorial disease that results from the interplay between environmental factors and a susceptible genetic background. Experimental autoimmune encephalomyelitis (EAE) has been widely used to investigate the mechanisms underlying MS pathogenesis. Chemokines, such as CCL2, are involved in the development of EAE. We have previously shown that thiamine defic...

Experimental autoimmune encephalomyelitis (EAE) is a disease that can be induced in Lewis rats by inoculating them with myelin basic protein (BP) emulsified in complete Freund's adjuvant. Rats spontaneously recover from EAE and subsequently become refractory to attempts to induce a second bout of EAE. Mechanisms involved in spontaneous recovery and acquired refractoriness to EAE were elucid...

introduction: multiple sclerosis (ms) is a chronic autoimmune disease with unknown etiology affecting the central nervous system. the prevalence of ms is highest where environmental supplies of vitamin d are lowest. some studies have shown a strong protective effect of vitamin d3 in experimental autoimmune encephalomyelitis (eae) a model of ms. however, it is not known whether vitamin d3 has a ...

Background: Exhaustive Aerobic Exercise (EAE) increases the production of free radicals and oxidative stress in body. One most effective approaches to reduce EAE-induced is antioxidant supplementation.
 Objectives: Therefore, present study investigated effect short-term Vitamin D (Vit D) supplementation on capacity inactive men following an EAE session.
 Methods: In this clinical tria...

Experimental autoimmune encephalomyelitis (EAE) is a well-established cell-mediated autoimmune inflammatory disease of the CNS, which has been used as a model of the human demyelinating disease. EAE is characterized by infiltration of the CNS by lymphocytes and mononuclear cells, microglial and astrocytic hypertrophy, and demyelination which cumulatively contribute to clinical expression of the...