OBJECTIVE Inflammation plays a key role in the pathophysiology of abdominal aortic aneurysms (AAAs). Newly discovered Sphingosine-1-Phosphate Receptors (S1P receptors) are critical in modulating inflammatory response via prostaglandin production. The aim of the current study was to investigate the expression of different S1P receptors in AAAs and compared with normal aortas at the protein level...

OBJECTIVE To assess the possible role of proinflammatory CD28- T cells in abdominal aortic aneurysms (AAAs). Animal studies and human tissue studies suggest a role for interferon (IFN)-gamma-producing T cells in the development and progression of AAAs. METHODS AND RESULTS Fluorescence-activated cells sorter analysis of peripheral blood samples and measurement of AAA size using sonography were...

BACKGROUND AT2 receptors have an unclear function on development of abdominal aortic aneurysms (AAAs), although a pharmacological approach using the AT2 receptor antagonist PD123319 has implicated a role. The purpose of the present study was to determine the role of AT2 receptors in AngII-induced AAAs using a combination of genetic and pharmacological approaches. We also defined effects of AT2 ...

Objective—The purpose of this study was to determine whether myeloid differentiation factor 88 (MyD88) and its related Toll-like receptors (TLRs) 2 and 4 contributed to the development of angiotensin II (AngII)-induced abdominal aortic aneurysms (AAAs) and atherosclerosis. Methods and Results—AngII was infused into either apoE Ϫ/Ϫ or LDL receptor (LDLR) Ϫ/Ϫ male mice that were either MyD88 ϩ/ϩ ...

Over the last decade, abdominal aortic aneurysm (AAA) has increasingly been recognized as an important cause of mortality in older persons. In 1999, for example, AAA was noted to be the 15th leading cause of mortality in the United States.1 Exact estimates of AAA-related fatalities are hampered by the low rate of postmortems when sudden death occurs in elderly subjects; however, recent figures ...