This work addresses the research and development (R&D) of an innovative optimization kernel applied to analog integrated circuit (IC) design. Particularly, this work focus is AIDA-CMK, by enhancing AIDA-C with a new multi-objective multi-constraint optimization kernel. AIDA-C is the circuit optimizer component of AIDA, an electronic design automation framework fully developed in-house. The prop...

The proliferation of mobile computers and wireless networks requires the design of future distributed real-time applications to recognize and deal with the significant asymmetry between downstream and upstream communication capacities, and the significant disparity between server and client storage capacities. Recent work proposed the use of Broadcast Disks as a scalable mechanism to deal with ...

We present an NMR-based antagonist induced dissociation assay (AIDA) for validation of inhibitor action on protein-protein interactions. As opposed to many standard NMR methods, AIDA directly validates the inhibitor potency in an in vitro NMR competition binding experiment. AIDA requires a large protein fragment (larger than 30 kDa) to bind to a small reporter protein (less than 20 kDa). We sho...

In this paper, we propose a superior technique for distributed time-critical communication using AIDA, a novel elaboration on Michael O. Rabin's IDA A 1 9 ]. We s h o w that using a small dynamically-controlled amount of redundancy, stringent timing constraints imposed on periodic as well as sporadic communication requests in a distributed real-time system can be fulllled up to any degree of co...

MOTIVATION Most proteins consist of multiple domains, independent structural and evolutionary units that are often reshuffled in genomic rearrangements to form new protein architectures. Template-based modeling methods can often detect homologous templates for individual domains, but templates that could be used to model the entire query protein are often not available. RESULTS We have develo...

To optimize antigen delivery by Salmonella vaccine strains, a system for surface display of antigenic determinants was established by using the autotransporter secretion pathway of gram-negative bacteria. A modular system for surface display allowed effective targeting of heterologous antigens or fragments thereof to the bacterial surface by the autotransporter domain of AIDA-I, the Escherichia...

The number of scientific articles has grown rapidly over the years and there are no signs that this growth will slow down in the near future. Because of this, it becomes increasingly difficult to keep up with the latest developments in a scientific field. To address this problem, we present here an approach to help researchers learn about the latest developments and findings by extracting in a ...

The influence of the blockade of group I metabotropic glutamate receptors (mGluRs) by AIDA [(RS)-1-aminoindan-1,5-dicarboxylic acid] on some behavioral effects was tested in control groups of rats and in rats that underwent short-term hypoxia. We used the following methods: the open field test, the passive avoidance test and the elevated "plus" maze test. In rats without hypoxia, AIDA (100 nmol...

Motivation: We address the following question: Does inhibition of the expression of a gene X in a cellular assay affect the expression of another gene Y? Rather than inhibiting gene X experimentally, we aim at answering this question computationally using as the only input observational gene expression data. Recently, a new statistical algorithm called Intervention calculus when the Directed ac...

The present study established a rat cortical neuronal model of in vitro mechanical injury. At 30 minutes after injury, the survival rate of the injured cortical neurons was decreased compared with normal neurons, and was gradually decreased with aggravated degree of injury. Reverse transcription-polymerase chain reaction results showed that at 1 hour after injury, there was increased expression...