Background. Isavuconazole (ISA) is a once-daily, extended-spectrum triazole approved for treatment of invasive aspergillosis and mucormycosis. The pharmacokinetic profile, daily dosing, lack of therapeutic drug monitoring (TDM) and reduced cost make ISA a promising option for use as prophylaxis for invasive fungal infections (IFIs). We report our experience with use of ISA for prophylaxis of IF...

This study is a part of an ongoing ISA project in Denmark. Its aim was to clarify two human factors issues, (1) the difference in attitude between ISA-volunteers and non-volunteers, and (2) the relative impact on speeding of two factors, ISA-information and driver motivation. The first part of the study compared survey data from ISA-volunteers with those of non-volunteers. The two groups differ...

Background. Isavuconazole (ISA) is a once-daily, extended-spectrum triazole approved for treatment of invasive aspergillosis and mucormycosis. The pharmacokinetic profile, daily dosing, lack of therapeutic drug monitoring (TDM) and reduced cost make ISA a promising option for use as prophylaxis for invasive fungal infections (IFIs). We report our experience with use of ISA for prophylaxis of IF...

Background. Isavuconazole (ISA) is a once-daily, extended-spectrum triazole approved for treatment of invasive aspergillosis and mucormycosis. The pharmacokinetic profile, daily dosing, lack of therapeutic drug monitoring (TDM) and reduced cost make ISA a promising option for use as prophylaxis for invasive fungal infections (IFIs). We report our experience with use of ISA for prophylaxis of IF...

INTRODUCTION Immunosuppressive agents (ISA) have been used in multiple sclerosis (MS) for decades, frequently as off label licensed therapies. Given the new MS treatment landscape, what place do ISA have in combating MS? METHODS We conducted a retrospective multicentre study to investigate the frequency of ISA prescription in 17 Italian MS centres, and to describe the clinical factors related...

Automatic acquisition of ISA relations is a basic problem in knowledge acquisition from text. We present an iterative method extracting ISA relations from large Chinese free text for ontology learning. Firstly, it initially discovers a set of sentences using several special Chinese lexico-syntactic patterns from free text corpus. Secondly we combine outside layer removal and inside layer gather...

Impervious surface area (ISA), one of the consequences of suburban sprawl, has emerged as a key indicator to explain and predict ecosystem health in relationship to watershed management. Quantifying precisely the spatial locations and distributions of ISA is essential for environmental monitoring and management. Classification of high spatial resolution remote sensing data is an important step ...