Intron splicing in eukaryotic organisms requires the interactions of five snRNAs and numerous different proteins in the spliceosome. Although the molecular mechanism behind splicing has been well studied, relatively little is known about regulation of expression for these splicing factor proteins. One of these proteins is the evolutionarily-conserved Drosophila RNP-4F splicing assembly factor. ...

Herein we present a Ligand Field Density Functional Theory (LFDFT) based methodology for the analysis of the 4f(n)→ 4f(n-1)5d(1) transitions in rare earth compounds and apply it for the characterization of the 4f(2)→ 4f(1)5d(1) transitions in the quantum cutter Cs2KYF6:Pr(3+) with the elpasolite structure type. The methodological advances are relevant for the analysis and prospection of materia...

It was hypothesized that the four-factor prothrombin complex concentrate (4F-PCC) Kcentra 25 unit/kg would reverse impairment of thrombin generation in healthy volunteers dosed with apixaban to steady state. In this randomized, two-period crossover, assessor-blinded trial, 12 healthy subjects received 5 mg apixaban every 12 h. Three h after the fifth dose, four-factor prothrombin complex concen...

Many studies have described the determination of luminescence, radiotherapeutic applications, and development of chelators for lanthanide ions (Ln ) in the past several years. In the application of lanthanide ions for photometry, fluorometry and bioassay, the development of selective chelators and probes for lanthanide ions is important. The electronic configurations of lanthanide ions have 4f ...

With spin polarized electron spectroscopies, we have invest.igatrd ortleretl (:t1(0001) films deposited on W(110). The photoemission featilres of the gadoli~liu~n 5d sllrlacr state, the 4f levels, and the background exhibit considerable spin polarization alor~g tllc same direction in the plane of the film, indicative of ferromagnetic coupli~ig brlurrrlt I I I ( . surface and the bulk. The 4f sp...

Using femtosecond time-resolved resonant magnetic x-ray diffraction at the Ho L_{3} absorption edge, we investigate the demagnetization dynamics in antiferromagnetically ordered metallic Ho after femtosecond optical excitation. Tuning the x-ray energy to the electric dipole (E1, 2p→5d) or quadrupole (E2, 2p→4f) transition allows us to selectively and independently study the spin dynamics of the...

We report bulk 4f and non-4f spectral functions near the Fermi level (EF) of a Kondo semiconductor CeRhAs and its related compound CePdSn by virtue of high-resolution soft X-ray photoemission. The non-4f spectrum of CeRhAs measured at 20K shows a shoulder at the binding energy of 0:18 eV and almost negligible spectral weight at EF: Although a peak similar to a tail of the Kondo resonance is obs...

4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar excess of apoA-I. Physiologic concentrations ( approximately 35 microM) of human apoA-I did not inhibit the production of LDL-induced monocyte chemotactic activity by human aortic endothelial cell cultures, but adding nanomolar concentration...

AIMS: Cardiac dysfunction is a complication of sepsis and contributes to morbidity and mortality. Since raising plasma apolipoprotein (apo) A-I and high density lipoprotein (HDL) concentration reduces sepsis complications, we tested the hypothesis that the apoA-I mimetic peptide 4F confers similar protective effects in rats treated with lipopolysaccharide (LPS). METHODS AND RESULTS: Male Sprag...

The interaction of three protein synthesis initiation factors, eukaryotic initiation factor (eIF)-4A, -4B, and -4F, with mRNA has been examined. Three assays specifically designed to evaluate this interaction are RNA-dependent ATP hydrolysis, retention of mRNAs on nitrocellulose filters, and cross-linking to periodate-oxidized mRNAs. The ATPase activity of eIF-4A is only activated by RNA which ...