The pathogenesis of acute myeloid leukemia (AML) involves the cooperation of mutations promoting proliferation/survival and those impairing differentiation. The RAS pathway has been implicated as a key component of the proliferative drive in AML. We have screened AML patients, predominantly younger than 60 years and treated within 2 clinical trials, for NRAS (n = 1106), KRAS (n = 739), and HRAS...

10-Year survival (10YS) after radical surgery for gastric cancer (GC) patients (GCP) (T1-4N0-2M0) was analyzed. We analyzed data of 796 consecutive GCP (age=57.1±9.4 years; tumor size=5.4±3.1 cm) radically operated (R0) and monitored in 1975-2021 (m=556, f=240; distal gastrectomies-G=461, proximal G=165, total G=170, D2 lymph node dissection=551; combined G with resection 1-7 adjacent organs (p...

As a resource for vertebrate phylogenetics, we developed 75 new protein-coding genes using a combination of expressed sequence tags (ESTs) available in Genbank, and targeted amplification of complementary DNA (cDNA). In addition, we performed three additional analyses in order to assess the utility of our approach. First, we profiled the phylogenetic informativeness of these new markers using t...

The yield responses of sugarcane to lime and gypsum at two sites in the KwaZulu-Natal Midlands of South Africa are presented and discussed. At Dalton, on a Magwa form soil with an initial aluminium saturation index (ASI) of >80%, over a plant and four ratoon crops variety N12 gave no significant response to dolomitic lime. By contrast, variety N16 gave consistent yield responses to lime at rate...

In this appendix, we first describe the mathematical derivation of the marginal likelihood of model Mh: P (G|Mh) (Section 2). Then we show four equivalent formulas for solving P (G|Mh) (Section 3). After that, we show how to obtain the marginal likelihood of model Ml from the solution to the marginal likelihood of model Mh (Section 4). Finally, we show that the overall computational complexity ...

∗This work was financially supported by the Austrian Science Foundation (FWF) grant SFB F013 and the Christian Doppler Research Association (CDG). S. Gerhold gratefully acknowledges a fruitful collaboration and continued support by the Austrian Federal Financing Agency and Bank Austria through CDG. M. Kauers was supported by the Austrian Science Foundation FWF under SFB F013 grant number F1305 ...

Method We analyzed data of 491 consecutive ECP (age = 56.2 ± 8.8 years; tumor size = 6.3 ± 3.4 cm) radically operated and monitored in 1975-2015 (m = 359, f = 132; EG Garlock = 280, EG Lewis = 211, combined EG with resection of pancreas, liver, diaphragm, aorta, VCS, colon transversum, lung, trachea, pericardium, splenectomy = 147; adenocarcinoma = 279, squamous = 202, mix = 10; T1 = 90, T2 = 1...