IA-2 (islet cell Ag 512) and IA-2 beta (phogrin/IAR) are related autoantigens associated with type 1 diabetes. To determine the critical regions for autoantibody binding and which of these autoantigens is the primary target, mutant and chimeric constructs were used to characterize Ab epitope binding in sera from 217 new onset patients with type 1 diabetes and sequential samples from 141 islet c...

The I region of the mouse H-2 complex is divided into subregions, I-A, I-B, I-J, I-E, and I-C, that are marked by the Ia-1, Ia-2, Ia-4, Ia-5, and Ia-3 loci, respectively (1, 2). The Ia-1, Ia-5, and Ia-3 locus structural products are Ia antigens, a group of polymorphic, cell-surface glycoproteins that consist of two noncovalently associated polypeptide chains of mol wt =30,000-35,000 (a-subunit)...

The Ia antigens of the guinea pig have been shown to play a central role in the regulation of the immune response. We have previously partially characterized the chemical structure of these antigens. In this communication, we further characterize the structure of the five Ia antigens already described, as well as two new Ia antigens. Evidence is presented which shows that these seven Ia antigen...

The I region of the mouse H-2 complex is divided into subregions, I-A, I-B, I-J, I-E, and I-C, that are marked by the Ia-1, Ia-2, Ia-4, Ia-5, and Ia-3 loci, respectively (1, 2). The Ia-1, Ia-5, and Ia-3 locus structural products are Ia antigens, a group of polymorphic, cell-surface glycoproteins that consist of two noncovalently associated polypeptide chains of mol wt =30,000-35,000 (a-subunit)...

Information regarding the processes leading to death in patients with invasive aspergillosis (IA) is lacking. We sought to determine the causes of death in these patients, the role that IA played in the cause, and the timing of death. The factors associated with IA-related mortality are also analyzed. We conducted a multicenter study (2008-2011) of cases of proven and probable IA. The causes of...

Observations of Type Ia supernovae (SNe Ia) reveal correlations between their luminosities and light-curve shapes, and between their spectral sequence and photometric sequence. Assuming SNe Ia do not evolve at different redshifts, the Hubble diagram of SNe Ia may indicate an accelerating Universe, the signature of a cosmological constant or other forms of dark energy. Several studies raise conc...