A recent phase 3 trial of prucalopride in children with functional constipation (SPD555-303 ClinicalTrials.gov Identifier: NCT01330381) reported negative efficacy results. Here, we developed a population pharmacokinetic (PK) model of prucalopride in children to assess prucalopride exposure in SPD555-303. An initial population PK model in children was developed based on sampled single-dose data ...

Steroids in back pain Well, we’ve tried them for just about everything else so there is perhaps no surprise that researchers in Australia have investigated the use of single dose steroids in the treatment of low back pain with radiculopathy. This randomized controlled trial demonstrates an interesting approach to a group of patients for whom we currently offer little more than analgesia and sym...

This paper explores computational models of multi-party discourse, using transcripts from U.S. Supreme Court oral arguments. The turn-taking behavior of participants is treated as a supervised sequence labeling problem and modeled using firstand secondorder Conditional Random Fields. We specifically explore the hypothesis that discourse markers and personal references provide important features...

We have built and evaluated a prototype of a tool called Knight. The tool uses an electronic whiteboard a large, touch sensitive computer screen (currently a SMART Board http://www.smarttech.com). The large drawing space resembles a traditional whiteboard: Pens are used as input devices and several persons can work around it. Thus, it naturally supports collaborative work. Furthermore, the Knig...

B. Anionic Ligands 302 IX. Group 9 Catalysts 302 X. Group 10 Catalysts 303 A. Neutral Ligands 303 1. R-Diimine and Related Ligands 303 2. Other Neutral Nitrogen-Based Ligands 304 3. Chelating Phosphorus-Based Ligands 304 B. Monoanionic Ligands 305 1. [PO] Chelates 305 2. [NO] Chelates 306 3. Other Monoanionic Ligands 306 4. Carbon-Based Ligands 306 XI. Group 11 Catalysts 307 XII. Group 12 Catal...

Doodle is a simple and popular online system for scheduling events. It is an implementation of the approval voting mechanism, where candidates are the time slots and each responder approves a subset of the slots. We analyze all the Doodle polls created in the US from JulySeptember 2011 (over 340,000 polls), consisting of both hidden polls (where you cannot see other people’s votes) and open pol...

Traditionally, behavioural and electrophysiological measurements in animals are performed separately; however their combined use has considerably enriched our understanding of, for example, memory-related processes. Especially single unit recordings paved the way and highlighted performance-specific firing characteristics of individual neurones (place cells, phase cell, head direction cell – se...