A5 noradrenergic neurons control sympathetic outflow, nociception, and respiration. The presence of α2-adrenergic receptors (α2-ARs) in A5 cells has been suggested by immunohistochemistry. In the present experiments, we analyze the response of spinally projecting A5 cells to α2-AR agonists, and we compare it with that of locus ceruleus (A6) neurons. Whole cell recordings were obtained from 52 s...

Huangfu, Donghai, and Patrice G. Guyenet. Autoactivity of A5 neurons: role of subthreshold oscillations and persistent Na1 current. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2280–H2289, 1997.—A5 noradrenergic neurons play a key role in autonomic regulation, nociception, and respiration. The purpose of the present experiments was to characterize some of the intrinsic properties of A5 cells...

An attack on the A5/2 stream cipher algorithm is described, that determines the linear relations among the output sequence bits. The vast majority of the unknown output bits can be reconstructed. The time complexity of the attack is proportional to 2. Introduction: A5 is the stream cipher algorithm used to encrypt the link from the telephone to the base station in the GSM system. According to [...

Sea cucumber extracts have been widely used to treat individuals with inflammatory conditions in East Asia. The present study has been designed to test potential colon cancer-preventive properties of Frondanol A5, a glycolipid extract from the sea cucumber, Cucumaria frondosa, using in vivo and in vitro models of colon cancer. Chemopreventive efficacy of Frondanol A5 was evaluated on azoxymetha...

G. A. van Tilborg, G. J. Strijkers, H. Duimel, P. Bomans, P. M. Frederik, C. P. Reutelingsperger, K. Nicolay Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, EM unit, Department of Pathology, University of Maastricht, Maastricht, Netherlands, Cardiovascular Research Institute of Maastricht, Department of Biochemistry, Maastricht U...

Let Gn be a double cover of either the alternating group An or the symmetric group Sn, and let Gn−1 be the corresponding double cover of An−1 or Sn−1. For every odd n ≥ 3 and every field k of characteristic 0, we prove that the following are equivalent: (i) there exists a generic extension for Gn−1 over k, (ii) there exists a generic extension for Gn over k. As a consequence, there exists a gen...

The phenotype of excitatory cerebral cortex neurons is specified at the progenitor level, orchestrated by various intrinsic and extrinsic factors. Here, we provide evidence for a subcortical contribution to cortical progenitor regulation by thalamic axons via ephrin A5-EphA4 interactions. Ephrin A5 is expressed by thalamic axons and represents a high-affinity ligand for EphA4 receptors detected...

The molecular mechanisms that coordinate the functional organization of the mammalian neocortex are largely unknown. We tested the involvement of a putative guidance label, ephrin-A5, in the functional organization of the somatosensory cortex by quantifying the functional representations of individual whiskers in vivo in adult ephrin-A5 knock-out mice, using intrinsic signal optical imaging. In...

Cisplatin is a member of platinum-containing anti-cancer drugs that causes cross-linking of DNA and ultimately cancer cell apoptosis. The therapeutic function of cisplatin on various types of cancers has been widely reported but the side effects have been discovered together and nephrotoxicity has been regarded as major side effect of cisplatin. To select candidates for new sensitive nephrotoxi...

Eph receptor tyrosine kinases and ephrins are required for axon patterning and plasticity in the developing nervous system. Typically, Eph-ephrin interactions promote inhibitory events; for example, prohibiting the entry of neural cells into certain embryonic territories. Here, we show that distinct subsets of motor neurons that express EphA4 respond differently to ephrin-A5. EphA4-positive LMC...