نتایج جستجو برای: آنتی tumor necrosis factor tnf

تعداد نتایج: 1254222  

Journal: :Biomedicines 2021

Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand (CD40-CD40L) is a key receptor–ligand signaling pair involved the adaptive immune response and pathogenesis of autoimmune diseases. In mice, CD40 activation leads to sickness behavior syndrome (SBS) comprising weight loss, sleep disruption depression, which can be blocked by administration TNF-in...

Journal: :Brazilian Journal of Case Reports 2023

The use of tumor necrosis factor (anti-TNF) antagonists has become a practice applied in the treatment various inflammatory diseases, such as psoriasis. However, Anti-TNF can, paradoxically, trigger side effects form psoriasiform or worsening pre-existing symptoms, patients with without previously diagnosed In view this, two case reports were described. First, we described 21-year-old female pa...

Journal: :Journal of the American College of Cardiology 2002
Naoya Maekawa Hisayasu Wada Tsugiyasu Kanda Tamikazu Niwa Yasuhiro Yamada Kuniaki Saito Hisayoshi Fujiwara Kenji Sekikawa Mitsuru Seishima

OBJECTIVES This study sought to assess the role of tumor necrosis factor-alpha (TNF-alpha) in myocardial ischemia/reperfusion (I/R) injury using TNF-alpha knockout (KO) mice. BACKGROUND Tumor necrosis factor-alpha is thought to be involved in the pathogenesis of myocardial I/R injury by promoting leukocyte infiltration of the myocardium. However, the precise role of TNF-alpha in I/R injury is...

Tumor necrosis factor alpha (TNF-α) expression amplifies to excess amounts in several disorders such as rheumatoid arthritis and psoriasis. Although, Anti-TNF biologics have revolutionized the treatment of these autoimmune diseases, formation of anti-drug antibodies (ADA) has dramatically affected their use. The next generation antibodies (e.g. Fab, scFv) have not only reduced resulted immunoge...

Hossein Azadeh Mohammad Vahedi Saeid Abediankenari, Yousef Yousedzadeh

Background: Dendritic cells (DCs) are professional antigen presenting cells that have an important role in the initiation of immune response. The use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. Objective: In this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and CpG oligonucleotides in inducing d...

Journal: :گوارش 0
mehdi seilaniantoosi houshang rafatpanah jalil tavakkolafshar mohammadreza ghavamnassiri hamidreza sima mona malekzadehmoghani

background host genetic and environmental factors are involved in development of gastric cancer. tumor necrosis factor (tnf)-î±| has a key role in helicobacter pylori -induced gastritis. we analyzed the association between tnf-î± polymorphism and the risk of gastric cancer in an iranian population residing in northeastern iran. materials and methods in a case-control study, the genotyping was c...

Journal: :iranian red crescent medical journal 0
tao zhang department of gastrointestinal surgery, the center hospital of wuhan, wuhan, china; department of gastrointestinal surgery, the center hospital of wuhan, wuhan, china. tel/fax: +86-2782211448 hui wang department of gastrointestinal surgery, the center hospital of wuhan, wuhan, china liang han department of gastrointestinal surgery, the center hospital of wuhan, wuhan, china

conclusions traf6 plays an important role in the onset of colon cancer; therefore, drugs targeting it may have great clinical significance in the treatment of this disease. results the positive expression rate of traf6 in tumor tissues was 66.7%, which was significantly higher than in normal paracancerous tissues (18.5%). the positive expression rate of traf6 was significantly correlated with d...

2002
Hidekazu Kitakata Yoko Nemoto-Sasaki Yutaka Takahashi Toshikazu Kondo Masayoshi Mai Naofumi Mukaida

Intrasplenic administration of a colon adenocarcinoma cell line, colon 26, induced tumor necrosis factor (TNF) protein expression around the central and portal veins of the liver at 3 days, and liver metastases by 24 days after the tumor injection, in 90% of wild-type (WT) mice. To explore the roles of TNFin the process, we administered colon 26 cells into tumor necrosis factor receptor p55 (TN...

2014
David S Pisetsky

Among targets of biological agents, tumor necrosis factor remains in the exclusive group that has retained its historical name or at least one of them. Tumor necrosis factor is usually known by the three-letter abbreviation TNF and somehow has escaped a more bland and nondescript moniker such as IL-something. Endogenous pyrogen is now IL-1, B-cell stimulatory factor-2 is now IL-6, and T-cell gr...

Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...

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