BACKGROUND Cytomegalovirus (CMV) is one of the most important opportunistic infections in transplant recipients. Currently sero-positivity for CMV IgG before solid organ transplantation is the laboratory test of choice for stratifying the risk of CMV reactivation after solid organ transplantation. Theoretically, CMV-specific cell-mediated immune responses before solid organ transplantation shou...

BACKGROUND The mechanisms responsible for the increased susceptibility of fetuses to cytomegalovirus (CMV) were studied by comparing CD8(+) T cell responses to the virus in susceptible fetuses to those in their comparatively more resistant mothers. METHODS Included in the study were 16 transmitter mothers who underwent seroconversion during the first trimester of pregnancy as well as their fe...

We have identified a cytomegalovirus virion protein capable of modulating the rapid induction of an interferon-like response in cells that follows virus binding and penetration. Functional genomics revealed a role for the major cytomegalovirus structural protein, pp65 (ppUL83), in counteracting this response. The underlying mechanism involves a differential impact of this structural protein on ...

objectives: human cytomegalovirus (cmv) is a major life-threatening pathogen for hematopoietic stem cell transplant recipients. specific tests are used for the diagnosis and monitoring of cmv infection in transplant patients. this study evaluates the performance of pp65 antigenemia and qualitative pcr assays for monitoring cmv in such patients. methods: we analyzed 179 clinical samples from 41...

The development of a protective cellular immune response line for lysis. In vitro immunization of PBMC from HLA A*0201 and HCMV seropositive volunteers using the defined against human cytomegalovirus (HCMV) is the most important determinant of recovery from HCMV infection after nonamer peptide stimulated significant recognition of HCMV infected or peptide-sensitized fibroblasts. Similarly, allo...

healthy people, a primary infection with human cytomegalovirus (HCMV) is often mild or even asympto-matic, but may cause a mononucleosis-like syndrome with fever, arthralgia, fatigue, thrombo cyto penia, and anemia. During acute infection, HCMV infection often leads to immune dysfunction, including both immuno-suppression and autoimmune phenomena. HCMV infection results in production of autoant...

BACKGROUND Arterial stiffness is a well-known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T-cell senescence. METHODS AND RESULTS Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans...

CMV remains an important opportunistic pathogen in solid organ transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient-; D+R-) are at high-risk for active CMV infection and increased mortality, however the immune correlates of viral control remain incompletely understood. We prospectively studied 23 D+R- LTRs during primary CMV infection to ...