Activator of G protein signaling 3 (AGS3) is a guanine nucleotide dissociation inhibitor (GDI) that contains four G protein regulatory (GPR) or GoLoco motifs in its C-terminal domain. The entire C-terminal domain (AGS3-C) as well as certain peptides corresponding to individual GPR motifs of AGS3 bound to G alpha i1 and inhibited the binding of GTP by stabilizing the GDP-bound conformation of G ...

Let I⊆R=K[x1,…,xn] be a toric ideal, i.e., binomial prime ideal. We investigate when the ideal I can “split” into sum of two smaller ideals. For general I, we give sufficient condition for this splitting in terms integer matrix that defines I. When I=IG is finite simple graph G, additional splittings IG related to subgraphs G. there exists I=I1+I2 show some cases describe (multi-)graded Betti n...

Let X ,Y are linear space. In this paper, we prove the generalized Hyers-Ulam stability of the following quartic equation n ∑ k=2 ( k ∑ i1=2 k+1 ∑ i2=i1+1 . . . n ∑ in−k+1=in−k+1 ) f ( n ∑ i=1,i =i1,...,in−k+1 xi − n−k+1 ∑ r=1 xir )

The articles [11], [7], [14], [13], [15], [5], [6], [2], [12], [1], [10], [8], [9], [3], and [4] provide the notation and terminology for this paper. For simplicity, we adopt the following rules: A, B denote ordinal numbers, K, M, N denote cardinal numbers, x, y, z, X , Y , Z, Z1, Z2 denote sets, n denotes a natural number, and f , g denote functions. Let I1 be a function. We say that I1 is car...

Two methods are compared for measuring the kinetic parameters of apolipoprotein A-I and A-I1 metabolism in human plasma. In the first, high density lipoprotein apoproteins were radioiodinated in situ in the lipoprotein particle (endogenous apoprotein labeling) while in the second, individually labeled apolipoprotein A-I or A-I1 was incorporated into the particle by in vitro incubation (exogenou...

Cilia and flagella are highly conserved motile and sensory organelles in eukaryotes, and defects in ciliary assembly and motility cause many ciliopathies. The two-headed I1 inner arm dynein is a critical regulator of ciliary and flagellar beating. To understand I1 architecture and function better, we analyzed the 3D structure and composition of the I1 dynein in Chlamydomonas axonemes by cryoele...

The cardiac muscle protein titin, responsible for developing passive elasticity and extensibility of muscle, possesses about 40 immunoglobulin-like (Ig) domains in its I-band region. Atomic force microscopy (AFM) and steered molecular dynamics (SMD) have been successfully combined to investigate the reversible unfolding of individual Ig domains. However, previous SMD studies of titin I-band mod...