In this paper we present the results of both experimental investigation and analytical modelling of γ-irradiation effects on basic electrical characteristics of power VDMOS transistors. First, an analytical model that yields the drain current and transconductance dependencies on gate oxide charge density is developed. The experimental data are utilized to establish an analytical relation betwee...

This paper introduces instrumental photon activation analysis (IPAA) utilizing short-lived products of photonuclear reactions, mainly (γ, n) and p), initiated by bremsstrahlung from the MT-25 microtron. A rapid nondestructive IPAA method for geochemical major element is introduced as a tool basic characterization rocks. Procedures were developed parameters such beam energy irradiation-decay-cou...

The present studies investigated the cellular mechanisms for the detrimental effects of high dose whole body γ-irradiation on bone. In addition, radioadaptation and bone marrow transplantation were assessed as interventions to mitigate the skeletal complications of irradiation. Increased trabecular thickness and separation and reduced cancellous bone volume fraction, connectivity density, and t...

A convenient synthetic approach to α,β-unsaturated γ-butyrolactones and α,β-unsaturated γ-butyrolactams is developed. The reaction proceeds via decarboxylative iodination of paraconic acids and β-carboxyl-γ-butyrolactams, employing 1,3-diiodo-5,5-dimethylhydantoin (DIH) under irradiation, followed by dehydroiodination of β-iodo-γ-butyrolactones and γ-butyrolactams providing good yields of α,β-u...

The aim of the investigation was to reveal changes in neurons cerebral cortex depending on dose γ-irradiation, rate exposure, mode exposure (acute and chronic) establish priority each influencing factors (γ-irradiation, recovery time their joint impact) end result. Material methods . experiment, compliance with rules bioethics, carried out 300 adult white rats that were exposed acute chronic γ-...

High-dose ionizing irradiations can cause acute tissue and organ damage, especially severe cutaneous lesions. These cutaneous injuries often result in further complications and incur high mortality. Therefore, it is critical to develop effective therapeutic approaches for acute high-dose ionizing irradiation injury. Intracellular reactive oxygen species (ROS) have been implicated in mediating i...

Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with PC12 cells. Chronic irradiation at 0.027 mGy/min resulted in inhibition of NGF-induced n...

PURPOSE To evaluate the usefulness of combined treatment with continuous administration of a hypoxic cytotoxin, tirapazamine (TPZ), and mild temperature hyperthermia (MTH) in γ-ray irradiation in terms of local tumour response and lung metastatic potential, referring to the response of intratumour quiescent (Q) cells. MATERIALS AND METHODS B16-BL6 melanoma tumour-bearing C57BL/6 mice were con...

The ATM kinase plays a critical role in initiating the DNA damage response that is triggered by genotoxic stresses capable of inducing DNA double-strand breaks. Here, we show that ELF4/MEF, a member of the ETS family of transcription factors, contributes to the persistence of γH2AX DNA damage foci and promotes the DNA damage response leading to the induction of apoptosis. Conversely, the absenc...

BACKGROUND γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation induces de novo protein synthesis and enhances antigen presentation, we therefore investigated whether γ-radiation results in increased expression of cancer-testis (CT) antigens and MHC-I, thus allowing efficient immunological contr...