Transforming growth factor (TGF-β1) is among the strongest factors of liver fibrogenesis, but its association with Schistosoma-caused liver fibrosis is controversial. Tissue transglutaminase (tTG) is the principal enzyme controlling TGF-β1 maturation and contributes to Sj-infected liver fibrosis. Here we aim to explore the consistency between tTG and TGF-β1 and TGF-β1 source and its correlation...

Transforming Growth Factor β1 (TGF-β1) is a well-known neuroprotective and neurotrophic factor demonstrated to play a role in synaptic transmission. However, its involvement in physiological mechanisms underlying synaptic plasticity and memory at hippocampal level has not been thoroughly investigated. Here, we examine the role of TGF-β1 in hippocampal long-term potentiation (LTP) and memory in ...

Despite the extensive research conducted on relationship between transforming growth factor-beta 1 (TGF-β1) polymorphisms and levels onset development of liver disease, there are still certain gaps that need to be addressed. To address these provide a comprehensive overview current knowledge, this review aimed identify relevant published TGF-β1/TGF-β1 polymorphism, levels, their associations wi...

Background Wound healing is an essential physiological process in recovery after microsurgery. Objectives To further understand the functions of fibroblast growth factor 21 (FGF21), roles this were examined and its correlations with inflammation, vascular endothelial A (VEGFA) ERK1/2 signaling pathway activation analyzed. Material methods Rat brain microvascular cells (RBMECs) treated interleuk...

background: integrins are heterodimeric glycoprotein receptors that regulate the interaction of cells with extracellular matrix and may have a critical role in implantation. the aim of this study was to investigate the effect of ovulation induction on the expression of α4, αv, β1, and β3 integrins in mouse blastocyst at the time of implantation. methods: the ovarian stimulated and non-stimulate...

In fish immunity, the regulatory role of transforming growth factor-β1 (TGF-β1) has not been fully characterized. Here we examined the immunoregulatory effects of TGF-β1 in grass carp peripheral blood leukocytes (PBL) and head kidney leukocytes (HKL). It is interesting that TGF-β1 consistently stimulated the cell viability and the mRNA levels of pro-inflammatory cytokines (Tnfα and Ifnγ) and T/...

Background. Hepatitis B infection can lead to advanced liver disease (ALD) which causes serious health problems. Several factors that are thought play a role in P53, Transforming Growth Factor-β1 (TGF-β1), and Interleukin-10 (IL-10). Therefore, this study aimed determine the association between TGF-β1, IL-10 serum levels with ALD.Methods. We collected 68 sera from patients HBV infection. were m...

The critical involvement of TGF-β1 (transforming growth factor-β1) in DN (diabetic nephropathy) is well established. However, the role of CTGF (connective tissue growth factor) in regulating the complex interplay of TGF-β1 signalling networks is poorly understood. The purpose of the present study was to investigate co-operative signalling between CTGF and TGF-β1 and its physiological significan...

OBJECTIVE Targeted down-regulation of TGF-β expression inhibits invasion and metastasis in breast cancer cells. However, the mechanism that TGF-β functions by remains largely unknown. In the present study we report the mechanism of ERK1/2 dependant S100A4 regulation by TGF-β and its possible role in TGF-β-mediated tumour invasion in vitro. MATERIALS AND METHODS Small interfering RNA targeting...