The objective of this study was to evaluate the dynamics of tocopherols in cotyledons and radicles from sunflower seeds with high and low total tocopherol content, mainly in the α-tocopherol form, and from seeds with increased proportions of β-, γ-, and δ-tocopherol, both under dark and light conditions. Tocopherol content was measured every 24 h from 1 to 12 days after sowing. In all cases, th...

Background: Aging is associated with attenuation of immune responses. Studies show that old people are vulnerable to infectious diseases such as influenza. α-Tocopherol as an immunomodulator affects immune responses. In the present study, the effect of α-tocopherol, on lymphocyte responses i.e. interferon-gamma (IFN-γ), Tumor Necrosis Factor-alpha (TNF-α), and nuclear factor-κB (NF-κB)  in elde...

The phytosterol and tocopherol contents of almond kernel oil were evaluated in three cultivars, including the Spanish cultivar ‘Marcona’ French cultivars ‘Ferragnès’ ‘Ferraduel’, grown under two different agro-climatic conditions, Zaragoza (Spain) Meknès (Morocco). analysis variance showed significant effects genotype on content, Δ5-Avenasterol, Δ7-Campesterol, Stigmasterol isomers. location ef...

BACKGROUND Contrast-induced acute kidney injury (CI- AKI) increases the likelihood of patient morbidity and mortality following coronary procedures. Volume supplement with saline is the standard treatment to prevent CI-AKI. Additional antioxidant prophylaxis has often yielded conflicting results. The present study was conducted to examine the role of novel application vitamin E (tocopherol) in ...

Cancer development and progression are closely associated with inflammation. NF-κB (nuclear factor κB) provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of malignant cells to resist tumour surveillance mechanisms. NF-κB might also regulate tumour angiogenesis and invasiveness and the signalling pathways that mediate its activation provide...

The antioxidant properties of α-tocopherol have been proposed to play a beneficial chemopreventive role against cancer. However, emerging data also indicate that it may exert contrasting effects on the efficacy of chemotherapeutic treatments when given as dietary supplement, being in that case harmful for patients. This dual role of α-tocopherol and, in particular, its effects on the efficacy o...

Using global expression profiling and pathway analysis on α-tocopherol-induced gene perturbation in bovine cells, this study has generated comprehensive information on the physiological functions of α-tocopherol. The data confirmed α-tocopherol is a potent regulator of gene expression and α-tocopherol possesses novel transcriptional activities that affect essential biological processes. The gen...

The effect of feed supplementation with natural α-tocopherol, rosemary, green tea, grape seed and tomato extracts on the oxidative stability of broiler meat was investigated by measuring lipid oxidation, protein oxidation and α-tocopherol content of breast muscle. Supplementation with α-tocopheryl acetate at a dietary concentration of 200 ppm was used as a control. The broilers were fed a diet ...

Insulin resistance may enhance the neointima formation via increased oxidative stress. However, clinical trials investigating the benefit of antioxidant therapy with α-tocopherol showed negative results. Recent studies showed that chemical characteristics of γ-tocopherol are distinct from those of α-tocopherol. We hypothesized that γ-tocopherol is superior to α-tocopherol in preventing the neoi...

Human serum contains many different antioxidants which may be important in the maintenance of antioxidant status. β-carotene and lycopene are carotenoids with potent antioxidant activity. Carotenoids intake probably protects against cancers and may affect the risk of several chronic conditions. α-tocopherol is well known for its function as antioxidant and in reduction of heart disease and canc...