objective(s): protein kinase c (pkcα) is involved in modulating articular chondrocytes apoptosis induced by nitric oxide (no). hyaluronic acid (ha) inhibits nitric oxide-induced apoptosis of articular chondrocytes by protecting pkcα, but the mechanism remains unclear. the present study was performed to investigate the effects and mechanisms of pkcα regulate protective effect of hyaluronic acid....

The present study describes the phytochemical profile and antimicrobial activity of Matricaria chamomilla essential oil. The sample of essential oil was obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC–MS. A total 55 compounds were identified mainly including α-Pinene (22.11%), Camphene (10.8%), Sabinene (4%), Limonene(5.64%),1,8-Cineole(6.45%), Camphor (4%) a...

This work analyzed the chemical compositions and evaluated antioxidant cytotoxic activities of essential oils (EO) Eugenia patrisii (Epat), stipitata (Esti), Myrcia splendens (Mspl), sylvatica (Msyl), Psidium guajava (Pgua), guineense (Pgui-1 Pgui-2) from Brazilian Amazon. Sesquiterpenoids were found in high concentrations E. M. splendens, which rich E-caryophyllene (32.0% 45.8%); sylvatica, di...

BACKGROUND We previously described the visceral antinociceptive property of α-bisabolol (BISA) in mouse models of visceral nociception induced by cyclophosphamide and mustard oil (MO). This study examined the effect of BISA in mouse models of visceral nociception induced by acetic acid, capsaicin, formalin, and the contribution of the nitric oxide system, α2, KATP, 5-HT3 and TRPV1 receptors to ...

objective(s):dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as myrtus communis, laurus nobilis, and stachys byzantina. it has been shown that some of these medicinal plants such as s. byzantina attenuate dependence and toleran...

conclusions our findings indicate that fenofibrate (ppar-α agonist) is able to prevent dn progression and improve kidney performance during chronic uncontrolled hyperglycemia possibly through increase in no bioavailability of kidney. results fenofibrate did not change the blood glucose of normal or diabetic rats. diabetes increased the proteinuria (82%) and blood creatinine of diabetic rats (4....

BACKGROUND The current chemotherapy for cutaneous leishmaniosis (CL) has a series of drug limitations such as toxic side effects, long duration, high costs and drug resistance, which requires the development of new drugs or effective alternatives to the CL treatment. Essential oils (EOs) are complex mixtures of secondary metabolites from various plants. It has been shown that several EOs, or th...