Overexpression of the epithelial specific matrix metalloproteinase inatrilysin (MAT) has been correlated with enhanced tumorigenicity and tumor cell invasion using in vitro model systems. We have determined the effects of MAT expression on the development of mammary tumorigenesis using transgenic mice that express human MAT under the control of the mouse mammary tumor virus (MMTV)-long terminal...

Amitriptyline and Perphenazine in depressive ill ness: a controlled trial. I. Haider . . . . 195 Amnesic syndrome, the Grunthal-Störrmg case of.0. L. Zangwill .. .. .. .. i13 701 —¿ ————,—(C) .. .. .. .. 557 Amylobarbitone, cross-over study with Trimi 701 pramine. J. W. Hunter et a!. . . . . . . 667 —¿ sodium, controlled comparison with nitraze 383 pam (†̃Mogadon'). C. Davies an...

We suggest and investigate a scheme for non-deterministic noiseless linear amplification of coherent states using successive photon addition, (â(†))(2), where â(†) is the photon creation operator. We compare it with a previous proposal using the photon addition-then-subtraction, ââ(†), where â is the photon annihilation operator, that works as an appropriate amplifier only for weak light fields...

‚√§μ‘¥‡TM◊ÈÕπ‘a“À剫√— ®—¥‡aìπ‚√§Õÿ∫—μ‘ „À¡à∑’Ëæ∫„π‡¢μ‡Õ‡TM’¬μ–«—πÕÕ°‡©’¬ß„μâ ‡TM◊È Õ‰«√— π’È¡—°æ∫Õ¬Ÿà „π§â“ߧ“«„π °ÿ≈ Pteropus ‚¥¬¡’°“√·æ√à Ÿà§π·≈– ÿ°√‡aìπ §√—Èߧ√“« ·≈–∫“ߧ√—Èß·æ√à‰a¬—ß —μ«å‡≈’È¬ß TMπ‘ ¥Õ◊Ë π‰¥â ¥â «¬ ‡TM◊È Õ‰«√— π’È ¡’ °“√√“¬ß“π‡aì π §√—È ß·√°‡¡◊Ë Õ‡°‘ ¥°“√√–∫“¥Õ¬à “ß·æ√à À≈“¬„π ¡“‡≈‡ ́’ ¬„πaï æ.». 2541-2542 Õ¬à “ß‰√°Á μ“¡ ‡TM◊ËÕ«à“‡TM◊ÈÕ‰«√— π’È¡’°“√·æ√à°√–®“¬Õ¬Ÿà„π ÿ °√‡≈’È...

Selective placement of an aliphatic â-alanine (â) residue paired side-by-side with either a pyrrole (Py) or imidazole (Im) aromatic amino acid is found to compensate for sequence composition effects for recognition of the minor groove of DNA by hairpin pyrrole-imidazole polyamides. A series of polyamides were prepared which contain pyrrole and imidazole aromatic amino acids, as well as γ-aminob...

the Nuclear Regulatory Com mission (NRC) by the Society ofNuclear Medicine and the American College ofNuclear Physiciansover four years ago is finally getting some response. The reaction from the peti tion's original author, however, has been less than favorable. Carol S. Marcus, PhD, MD, Director of Nuclear Medicine and Outpatient Clinic atHarbor-UCLAMedicalCenter and the principalauthorof the...

Ú ̆ ‰ ‡ Ï , È Â ‡ · was an active, if not the most active, character throughout „ Â „ ’s reign. However, the character of È Â ‡ · and his brothers is foggy and puzzling. Although many of us have been taught to classify figures in Tanach into the roles of either ¢ ˆ „ È ̃ ¢ or ¢ ̄ ̆ Ú ¢ to further our understanding of the manifest context © Ù ̆ Ë ® and latent meaning © „ ̄ ̆ ® of the text, È Â ‡ · and ...

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...