The binding of zinc(II) ions to apo-(bovine erythrocytes superoxide dismutase) was studied by 1H n.m.r. spectroscopy. Two zinc(II) ions bind to each subunit of the apoenzyme, and the first has a binding constant at least an order of magnitude larger than the second. The nature of the spectral changes that occur on binding the first zinc(II) ion are interpreted in terms of a change in the struct...

393 Abstract: In this study we have showed that zinc ion has an inhibitory activity on imipenem and meropenem suspectibility of Pseudomonas aeruginosa. When zinc ion concentration of Mueller-Hinthon agar (MHA) media was gradually increased the zone diameters of imipenem and meropenem gradually decreased. So we concluded that zinc concentration in the media might effect imipenem and meropenem su...

Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the ...

Thermoanaerobacter brockii alcohol dehydrogenase (TbADH) catalyzes the reversible oxidation of secondary alcohols to the corresponding ketones using NADP(+) as the cofactor. The active site of the enzyme contains a zinc ion that is tetrahedrally coordinated by four protein residues. The enzymatic reaction leads to the formation of a ternary enzyme-cofactor-substrate complex; and catalytic hydri...

Flexible Zinc-Ion Batteries In article number 2207610, Fen Ran and co-workers report on their study using the salting out property in Hofmeister effect to enhance mechanical strength electrochemical stability of hydrogel electrolytes that exhibit tensile stress 1.5 MPa ionic conductivity 2.35 × 10−2 S cm−1 undergo over 9300 charging discharging cycles when applied flexible zinc ion batteries.

Despite being the subject of intensive investigations, many aspects of the mechanism of the zinc-dependent medium chain alcohol dehydrogenase (MDR) superfamily remain contentious. We have determined the high-resolution structures of a series of binary and ternary complexes of glucose dehydrogenase, an MDR enzyme from Haloferax mediterranei. In stark contrast to the textbook MDR mechanism in whi...

Zinc-Ion Hybrid Capacitors In article number 2200341, Shuanghao Zheng, Zhong-Shuai Wu and co-workers demonstrate a new strategy for the fabrication of shape-conformable all-3D-printed zinc-ion hybrid capacitors, including hierarchically porous micro-lattice cathodes, metal anode stabilizers, quasi-solid gel electrolytes plastic packages. This provides general innovative methodology constructing...

Metallo-β-lactamases are important as a major source of resistance of pathogenic bacteria to the widely used β-lactam antibiotics. They show considerable diversity in terms of sequence and are grouped into three subclasses, B1, B2 and B3, which share a common overall fold. In each case the active enzyme has binding sites for two zinc ions in close proximity, although the amino-acid residues whi...

Lanthanum zinc penta-borate, LaZnB(5)O(10), was synthesized by flux-supported solid-state reaction. It is a member of the LnMB(5)O(10) (Ln = rare earth ion and M = divalent metal ion) structure type. The crystal shows a three-dimensional structure constructed from two-dimensional {[B(5)O(10)](5-)}(n) layers with the lanthanum (coordination number nine) and zinc (coordination number six) ions fi...

Zinc@) complexes of macrocyclic polyamines 1,2 and 3 make good models for zinc enzyme (e.g., carbonic anhydrase, alcohol dehydrogenase, phosphatase) active centers. Intrinsic acid properties of Zn** pertinent to the biological functions are disclosed. Zinc(II) ion is not only important kinetically but it also plays an indispensable role thermodynamically.