Prothymosin alpha (ProTalpha) is a small acidic protein that is highly conserved among mammals. The human form has 110 amino acid residues (M.W. 12.1 kDa; pI approximately 3.5) and is found to be expressed in a wide variety of tissues. ProTalpha plays an essential role in cell proliferation and apoptosis, and it is involved in transcriptional regulation of oxidative stress-protecting genes. Des...

Botulinum neurotoxin serotype A (BoNTA) is highly toxic, and its antidote is currently unavailable. The essential light-chain subunit of BoNTA is a zinc endopeptidase that can be used as a target for developing antidotes. However, the development of high-affinity, small-molecule inhibitors of the endopeptidase is as challenging as the development of small-molecule inhibitors of protein-protein ...

The coordination mode to lithium, magnesium, calcium and zinc cations of racemic vs. enantiopure amino acids racetam APIs is analysed its effect on chiral selection critically reviewed. It shown that resolution in the solid state can be obtained via cocrystallization compounds with an achiral inorganic salt coformer, such as LiX (X=Cl, Br, I) or ZnCl2, which favour tetrahedral state. may take f...

The reaction mechanism of the Cu+-catalyzed introduction two all-carbon-substituted stereocenters in an ynamide system using a Grignard reagent, zinc carbenoid, and aldehyde, was investigated density-functional theory. In contrast to formation organocopper(I) compound subsequent carbocupration reaction, previously postulated as initial step, proved instead proceed through complexation substrate...

The alternate sigma factor sigH of Mycobacterium tuberculosis is expressed under stress and acts as a major regulator of several genes, including some other sigma factors and redox systems. While it is auto-regulated by its own promoter at the transcriptional level, its regulation at the post-translational level is through its cognate protein, an anti-sigma factor, RshA. Hither before RshA was ...

the antimicrobial activity of some novel ascorbic acid-metal complexes [bisascorbate complexes of copper (ii), zinc(ii), manganese (11), iron (111), cobalt(ii), lead(ii) and cadmium(ii)] was investigated. four standard strains of bacterial species - staphylococcus aureus, escherichia coli, bacillus subtilis and klebsiella pneumonia and four fungal species - trichophyton sp. penicillium sp., asp...

The phenoxido and alkoxido bridged neutral Zn(3) complex [Zn(3)(μ-H(2)bemp)(2)(μ(3)-emp)(2)] (1), with an angular Zn(3)(μ-OPh)(2)(μ-OEt)(2) core and capping nitrogen donors, was synthesized via simultaneous chelation-cum-bridging of the parent and hydrolysed ligands. Zinc(II) coordination triggered the solution phase imine (C=N) bond hydrolysis of H(3)bemp (2,6-bis-[(2-hydroxyethylimino)methyl]...

Abstract The contamination of environmental waters with heavy metals and radionuclides is increasing because rapid industrial population growth. removal these contaminants from water via adsorption onto metal nanoparticles an efficient promising technique to abate the toxic effects associated pollutants. Among nanoparticle adsorbents, zinc oxide (ZnONPs) have received tremendous attention owing...