Uranium mining waste piles, heavily polluted with radionuclides and other toxic metals, are a reservoir for bacteria that have evolved special strategies to survive in these extreme environments. Understanding the mechanisms of bacterial adaptation may enable the development of novel bioremediation strategies and other technological applications. Cell isolates of Bacillus sphaericus JG-A12 from...

Consider the diagonal action of the projective group PGL3 on n copies of P . In addition, consider the action of the symmetric group Σn by permuting the copies. In this paper we find a set of generators for the invariant field of the combined group Σn × PGL3. As the main application, we obtain a reconstruction principle for point configurations in P from their sub-configurations of five points....

INTRODUCTION We used DR1 transgenic mice and covalently linked DR1 multimers to characterize analog-specific inhibitory T cells in collagen-induced arthritis (CIA). Because of the low numbers of antigen-specific T cells in wild-type mice, functional T-cell studies in autoimmune arthritis have been challenging. The use of T-cell receptor (TCR) transgenic mice has provided useful information, but...

Appendix A. Results for Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A2 Appendix B. Use of 100 Bootstrapping Resamples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A12 Appendix C. Detailed Presentation, Studies 2 and 3 . . . . . . . . . . . . . . . . . . . . . . . ...

MAGE-A1, -A2, -A3, -A4, -A6, -A10, and -A12 are expressed in a significant proportion of primary and metastatic tumors of various histological types and are targets of tumor Ag-specific CTL. Individual MAGE-A expression varies from one tumor type to the other but, overall, the large majority of tumors expresses at least one MAGE-A Ag. Therefore, targeting epitopes shared by all MAGE-A Ags would...

A disintegrin and metalloproteinase 17 (ADAM17) regulates key cellular processes including proliferation and migration through the shedding of a diverse array of substrates such as epidermal growth factor receptor (EGFR) ligands. ADAM17 is implicated in the pathogenesis of many diseases including rheumatoid arthritis and cancers such as head and neck squamous cell carcinoma (HNSCC). As a centra...

We have previously shown that the leader proteinase (L(pro)) of foot-and-mouth disease virus (FMDV) blocks cap-dependent mRNA translation and that a genetically engineered FMDV lacking the leader proteinase coding region (A12-LLV2) is attenuated in cell culture and susceptible animals. The attenuated phenotype apparently is a consequence of the inability of A12-LLV2 to block the expression of t...

We study the minimal normal completion problem: given A ∈ Cn×n, how do we find an (n+q)×(n+q) normal matrix Aext := ( A A12 A21 A22 ) of smallest possible size? We will show that this smallest number q of rows and columns we need to add, called the normal defect of A, satisfies nd(A) ≥ max{i−(AA∗ −A∗A), i+(AA∗ −A∗A)}, where i±(M) denotes the number of positive and negative eigenvalues of the He...