We present recent results from a Keck study of the composition of the Galactic bulge, as well as results from the bulge Bulge Radial Velocity Assay (BRAVA). Culminating a 10 year investigation, Fulbright, McWilliam, & Rich (2006, 2007) solved the problem of deriving the iron abundance in the Galactic bulge, and find enhanced alpha element abundances, consistent with the earlier work of McWillia...

A comprehensive examination of the bulge motif is presented for a set of twenty single-base bulge structures obtained from the Protein Data Bank. Examples of the bulge motif found in X-ray-crystal and NMR structures are analyzed using molecular dynamics simulations. Three classes of the single-base bulge motif are defined according to the bulge residue type, and its surrounding basepairs. The f...

Massive Black Holes detected in the centers of many nearby galaxies show an approximately linear relation with the luminosity of the host bulge, with the black hole mass being 0.001-0.002 of the bulge mass. Previous work suggested that black holes of active (Seyfert 1) galaxies follow a similar relation, but apparently with a significantly lower value of MBH/Mbulge (Wandel 1999). New data show ...

DNA bulges are biologically consequential defects that can arise from template-primer misalignments during replication and pose challenges to the cellular DNA repair machinery. Calorimetric and spectroscopic characterizations of defect-containing duplexes reveal systematic patterns of sequence-context dependent bulge-induced destabilizations. These distinguishing energetic signatures are manife...

The Galactic bulge is the least studied component of our Galaxy. Yet, its formation and evolution are key to understand the formation of the Galaxy itself. Studies on the Galactic bulge have increased significantly in the last years, but still there are many points of controversy. This volume contains several contributions from experts in different aspects of the bulge. Issues discussed include...

The bacterial cell wall is conserved in prokaryotes, stabilizing cells against osmotic stress. Beta-lactams inhibit cell-wall synthesis and induce lysis through a bulge-mediated mechanism; however, little is known about the formation dynamics and stability of these bulges. To capture processes of different timescales, we developed an imaging platform combining automated image analysis with live...

The hair follicle bulge in the epidermis associates with the arrector pili muscle (APM) that is responsible for piloerection ("goosebumps"). We show that stem cells in the bulge deposit nephronectin into the underlying basement membrane, thus regulating the adhesion of mesenchymal cells expressing the nephronectin receptor, α8β1 integrin, to the bulge. Nephronectin induces α8 integrin-positive ...