Amplification of the Neu (ErbB-2 or HER-2) receptor tyrosine kinase occurs in 20 to 30% of human mammary carcinomas, correlating with a poor clinical prognosis. We have previously demonstrated that four (Y1144 Y1201, Y1227 and Y1253) of the five known Neu autophosphorylation sites can independently mediate transforming signals. The transforming potential of two of these mutants correlates with ...

Cellular effects of ethanol in YD-15 tongue carcinoma cells were assessed by MTT assay, caspase activity assay, Western blotting and flow cytometry. Ethanol inhibited the growth and proliferation of YD-15 cells in a dose- and time-dependent manner in an MTT assay. The effects of ethanol on cell cycle control at low percent range of ethanol concentration (0 to 1.5%), the condition not inducing Y...

Yindanxinnaotong (YD), a traditional Chinese medicine, has been introduced to clinical medicine for more than a decade, while its pharmacological properties are still not to be well addressed. This report aimed to explore the anti-atherosclerosis properties and underlying mechanisms of YD. We initially performed a computational prediction based on a network pharmacology simulation, which clued ...

This research aimed to compare the effects of pigments extracted from dried petal meal of marigold flower and synthetic pigments on productive performance of laying hens, egg quality and antioxidant properties of the egg. A total of 64 laying hens, aged 75 weeks, were distributed in a completely randomized design in 4 treatments and 4 replications containing 4 hens per cages. Experimental group...

Twenty multiparous Holstein cows, 4 of them surgically fitted with ruminal cannulas, were used in a replicated 4 x 4 Latin square to compare the effects of whole-plant silage and grain produced from NutriDense (ND), leafy NutriDense (LND), or a conventional yellow dent (YD) hybrid on ruminal fermentation, total tract nutrient digestibility, and performance of lactating dairy cows. On a DM basis...

The New York State Department of Health launched an innovative initiative, Assets Coming Together (ACT) for Youth, implemented in 2000, as a public health strategy to promote youth development (YD) as a means to improve health outcomes for youth. ACT for Youth shifted the focus from problems and problem reduction to assets and strength-based means of improving health by enhancing opportunities ...

determination of the accurate time of egg stripping after ovulation has been regarded as one of the most important factors in the successful reproduction of caspian brown trout(salmo trutta caspius). to determine the best time for egg stripping after ovulation and over- ripening of the oocyte in the caspian brown trout , the eggs of fish were retained in the coelomic cavity of females at 7 ± 6°...

Estimates of the radiocarbon age of seawater are required in correlations between marine and terrestrial records of the late Quaternary climate. We radiocarbon-dated marine shells and terrestrial plant remains deposited in two bays on Norway's west coast between 11,000 and 14,000 years ago, a time of large and abrupt climatic changes that included the Younger Dryas (YD) cold episode. The radioc...

In this paper we introduce a Jones-type invariant for singular knots, using a Markov trace on the Yokonuma–Hecke algebras Yd,n(u) and the theory of singular braids. The Yokonuma–Hecke algebras have a natural topological interpretation in the context of framed knots. Yet, we show that there is a homomorphism of the singular braid monoid SBn into the algebra Yd,n(u). Surprisingly, the trace does ...