The α2 adrenergic receptors which abundantly express in the CA1 region of the hippocampus play an important role in the regulation of sleep and memory retention processes. Based on the available evidence, the aim of our study was to investigate consequences of the activation and deactivation of CA1 α2 adrenergic receptors (by clonidine and yohimbine, respectively) on the impairment of memory re...

Bupropion is a unique and non-nicotine smoke cessation agent, it using drugs under FDA approval despite its antidepressant effect. In the current study, we considered short-term interaction of bupropion, adrenoceptors proprietary agonists antagonists (phenylephrine, prazosin, clonidine yohimbine) in intra VTA injection on naloxone precipitated withdrawal symptoms. The guide cannulae were implan...

the aim of the present study was to investigate the effect of α2-adrenergic agonist (xylazine) andantagonist (yohimbine) on phasic pain during estrous cycle in female rats. adult female rats weighing 180-220 g were kept under controlled temperature (21-24°c) and light/dark conditions (light on at 6:00 a.m. and light off at 6:00 p.m.). animals were divided into four groups: 1) control group whic...

Our aims were to assess the role of adrenergic modulation in the hyperventilation-induced increase in colonic tone. Of 40 healthy volunteers, 12 received placebo (saline) and the remaining 28 received either clonidine, yohimbine, phenylephrine, or ritodrine. Time-frequency mapping of heart rate based on Wigner distribution assessed variations in parasympathetic and sympathetic activity during h...

Objective- Medicinal plants and their active constituents are frequently used components for treating hyperglycemia. In the present study, the effect of curcumin was investigated on acute hyperglycemia and hyperinsulinemia induced by ketamine-xylazine in rats. To explore the possible mechanism, yohimbine (an α2-adrenergic receptor antagonist) was also used. Design...

Yohimbine is a potent and relatively nonselective 2-adrenergic receptor (AR) antagonist. In an earlier report, we demonstrated that dimeric yohimbine analogs containing methylene and methylene-diglycine tethers were highly selective human 2C-AR ligands. Little work has been done to examine the role of the tether group or the absence of the second yohimbine pharmacophore on selectivity for human...

Background—Coronary flow reserve (CFR) is not normalized shortly after coronary stenting. We hypothesized that -adrenergic coronary vasoconstriction acts to limit CFR. Methods and Results—We assessed flow velocity by Doppler wires and cross-sectional area by angiography in 46 patients undergoing coronary culprit lesion stenting (81 4% stenosis). Hyperemia was induced by adenosine (24 g IC or 14...

A new indole alkaloid, 12-hydroxy-N-acetyl-21(N)-dehydroplumeran-18-oic acid (13), and 11 known indole alkaloids: 3,4,5,6-tetradehydro-β-yohimbine (3), 19(E)-hunteracine (4), β-yohimbine (5), yohimbine (6), 19,20-dehydro-17-α-yohimbine (7), uleine (10), 20-epi-dasycarpidone (11), olivacine (8), 20-epi-N-nor-dasycarpidone (14), N-demethyluleine (15) and 20(E)-nor-subincanadine E (12) and a boone...