We propose a variant mix-net method, which we call a “marked mix-net” . Marked mix-nets avoid the extra cost associated with verifiability (producing a proof of correct mixing operation), while offering additional assurances about the privacy of the messages, compared to a non-verifiable mix-net. With a marked mix-net, each mix-server adds an extra secret mark in each ciphertext, and the input ...

This paper reports an analysis and comparison of the use of 51 different similarity coefficients for computing the similarities between binary fingerprints for both simulated and real chemical data sets. Five pairs and a triplet of coefficients were found to yield identical similarity values, leading to the elimination of seven of the coefficients. The remaining 44 coefficients were then compar...

Wombats are unique among marsupials in having one pair of upper incisors, and hypsodont molars for processing tough, abrasive vegetation. Of the three extant species, the most abundant, the common wombat (Vombatus ursinus), has had the least attention in terms of masticatory muscle morphology, and has never been thoroughly described. Using MRI and digital dissection to compliment traditional gr...

HPC applications commonly use Message Passing Interface (MPI) and SHMEM programming models to achieve high performance in a portable manner. With the advent of the Intel MIC processor technology, hybrid programming models that involve the use of MPI/SHMEM along with threading models (such as OpenMP) are gaining traction. However, most current generation MPI implementations are not poised to off...

Flexible docking and scoring using the internal coordinate mechanics software (ICM) was benchmarked for ligand binding mode prediction against the 85 co-crystal structures in the modified Astex data set. The ICM virtual ligand screening was tested against the 40 DUD target benchmarks and 11-target WOMBAT sets. The self-docking accuracy was evaluated for the top 1 and top 3 scoring poses at each...

Kinases regulate cell growth, movement, and death. Deregulated kinase activity is a frequent cause of disease. The therapeutic potential of kinase inhibitors has led to large amounts of published structure activity relationship (SAR) data. Bioactivity databases such as the Kinase Knowledgebase (KKB), WOMBAT, GOSTAR, and ChEMBL provide researchers with quantitative data characterizing the activi...