The importance of dissecting signaling pathways governing cell differentiation is based on their relevance not only for understanding basic biological phenomena but also better comprehending the underlying mechanisms pathologic alterations such as cancer. A paradigm processes hematopoiesis, where a single stem gives rise to multiple, fully differentiated, lineages. Nucleoredoxin (Nrx), member t...

Abstract The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the of multiple types cancer, its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an orally active selective inhibitor interaction between β-catenin CREB binding protein, which is part pathway, disrupts HEK293 adenomatous polyposis coli (APC)-m...

(1) Background: The purpose of this study was to investigate the effects low-dose non-thermal atmospheric plasma (NTP) on proliferation and migration human immortalized keratinocytes (HaCaT cells) its molecular mechanisms. (2) Methods: NTP HaCaT cells were detected by cell viability, wound healing assay, cycle, mitochondrial membrane potential detection, western blot, role reactive oxygen speci...

While investigating the role of p38 MAPK in regulating melanogenesis, we found that pyridinyl imidazole inhibitors class compounds as well as the analog compound SB202474, which does not inhibit p38 MAPK, suppressed both α-MSH-induced melanogenesis and spontaneous melanin synthesis. In this study, we demonstrated that the inhibitory activity of the pyridinyl imidazoles correlates with inhibitio...

Colorectal cancer (CRC) is the third most frequent and second leading cause of cancer-related deaths globally. Evidence shows that over 90% CRC cases are initiated by a deregulated Wingless Integrated Type-1 (WNT)/β-catenin signaling pathway. The WNT/β-catenin pathway also promotes cell proliferation, stemness, metastasis. Therefore, modulators may serve as promising regimens for CRC. This stud...

Introduction. Urotensin II (U II) is a kind of active peptide with variety biological effects, such as promoting cell proliferation and endocrine effects. The aim this study to investigate the effect urotensin on secretion vascular endothelial growth factor (VEGF) in cultured rat dermal papilla cells (DPCs), explore its molecular mechanism. Materials Methods. We used DPCs isolated from thoracic...

Hair follicle cyclical regeneration is regulated by epithelial-mesenchymal interactions. During androgenetic alopecia (AGA), hair stem cells (HFSC) differentiation impaired deregulation of dermal papilla (DPC) secreted factors. We analyzed androgen influence on BMPs expression in DPC and their effect HFSC to lineage. Androgens downregulated BMP2 BMP4 spheroids. Addition restored alkaline phosph...

The Wnt/β-catenin signaling pathway plays a major role in tissue homeostasis, and its dysregulation can lead to various human diseases. Aberrant activation of β-catenin is oncogenic and is a critical driver in the development and progression of human cancers. Despite the significant potential of targeting the oncogenic β-catenin pathway for cancer therapy, the development of specific inhibitors...

There has been increasing awareness of the importance of three-dimensional culture of cancer cells. Tumor cells growing as multicellular spheroids in three-dimensional culture, alternatively called organoids, are widely believed to more closely mimic solid tumors in situ. Previous studies concluded that the Wnt/β-catenin pathway is required for regeneration of the normal urothelium after injury...

In cancer, Wnt/beta-catenin signaling is ubiquitously referred to as an "oncogenic" pathway that promotes tumor progression. This review examines how the regulation and downstream effects of Wnt/beta-catenin signaling in cancer varies depending on cellular context, with a focus on malignant melanoma. We emphasize that the cellular homeostasis of Wnt/beta-catenin signaling may represent a more a...