The high rate of glycolysis in cancerous tissues, first described by Con in vivo (6) and by Warburg in vitro (@2),suggests that a considerable part of the energy supply for the neoplastic process is derived from the “anaerobic―phase of carbo hydrate catabolism. The low glycogen content characterizing a number of tumors (8—11, 13, I 7) may also indicate that the substrate for this process ...

Qualitative and quantitative differences of purified hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase were investigated in Wistar and Sprague-Dawley rats. Individual differences in the glucuronidation rate of androsterone and chenodeoxycholic acid were observed in hepatic microsomal fractions from Wistar but not Sprague-Dawley rats. No individual variation was observed in the glucuron...

The amount of DNA per nucleus in the adrenal medulla cells of four different strains of rats (Wistar, Sprague-Dawley, Long-Evans, and Italico) is determined both under control conditions and after 300 hr of intermittent exposure to cold. The adrenal medulla nuclei of the four strains of rats contain the same amount of DNA; however, the loss of DNA observed after the same experimental treatment ...

The purpose of this study was to determine and compare the Vertebral Heart Size (VHS) Cardio-Thoracic Rate (CTR) in normal Wistar Rats. size organs chest cavity heart can be measured by taking thorax radiographs. Thorax radiographs 85 male rats were taken under anesthesia, VHS CTR calculated digital environment. mean 7.22 mm right lateral position 7.34 left position. In radiography ventrodorsal...

AIM The present study was undertaken to study the pathology and control of sudden unexplained mortality in wistar rats. MATERIALS AND METHODS This study was conducted in a colony of 25 male wistar rats where there was mortality of nine rats. The dead rats were subjected to thorough post-mortem examination and necropsy samples were processed for hematoxylin and eosin staining for histopatholog...

Cellular dimensions in mesenteric resistance vessels from 10 spontaneously hypertensive rats and 10 Wistar-Kyoto rats have been determined using a random volume with an unbiased counting rule as the counting unit (the disector). With this method, vessels first were mounted on a myograph. Media thickness (spontaneously hypertensive rats, 11.3 micron; Wistar-Kyoto rats, 8.6 micron; P less than 0....

We have previously reported that there is a poor correlation between increase in the levels of UDP-glucuronosyltransferases, UGT1A1 and UGT1A6, and decrease in the levels of serum total thyroxine (T4) and free T4 in phenobarbital (PB)-treated rats, although the PB-induced decrease in rats is generally thought to occur through induction of the UDP-glucuronosyltransferase (T4-UDP-GT: UGT1A1 and U...

D-Galactosamine is one among the most experimentally used drug to study hepatotoxic effects in experimental animals. The model system of liver damage produced by D-galactosamine rats recognized be much like viral hepatitis humans from both morphological and functional points view. It also causes oxidative stress rats. Ajaswagandhadhi Lehyam has ingredients that reduce stress. This deals antioxi...

The aim of this work was to elucidate the possible role of glucocorticoids in the bacterial lipopolysaccharide (LPS)-induced decrease in hepatic IGF-I synthesis. For this purpose, we studied the effect of LPS on IGF-I in two rat strains, Wistar and Lewis, which have different adrenal responses to inflammation. Compared with Wistar rats, Lewis rats have a reduced hypothalamic-pituitary-adrenal r...