Mutations in the human neurotrypsin gene are associated with autosomal recessive mental retardation. To further understand the pathophysiological consequences of the lack of this serine protease, we studied Tequila (Teq), the Drosophila neurotrypsin ortholog, using associative memory as a behavioral readout. We found that teq inactivation resulted in a long-term memory (LTM)-specific defect. Af...

Detailed knowledge of the developmental process from single cells scattered on a surface to complex multicellular biofilm structures is essential in order to create strategies to control biofilm development. In order to study bacterial migration patterns during Pseudomonas aeruginosa biofilm development, we have performed an investigation with time-lapse confocal laser scanning microscopy of bi...

decline in timber harvesting from federal forests. The harvest of these products involves complex and interrelated social, economic, managerial, nd biological issues ( ee Savage 1995; Molina et al. 1997). Although timber typically exceeds nontimber forest products in value, opportunities xist o manage for both, to the benefit of different groups. Of nontimber products, the wild mushroom industr...

The conserved Eph receptors and their Ephrin ligands regulate a number of developmental processes, including axon guidance. In contrast to the large vertebrate Eph/Ephrin family, Drosophila has a single Eph receptor and a single Ephrin ligand, both of which are expressed within the developing nervous system. Here, we show that Eph and Ephrin can act as a functional receptor-ligand pair in vivo....

Two strains of Pleurotus giganteus (commercial and wild) were tested for their ability to induce neurite outgrowth in rat pheochromocytoma (PC12) and mouse neuroblastoma-2a (N2a) cells. Treatment with the mushroom extracts resulted in neuronal differentiation and neuronal elongation, but not nerve growth factor (NGF) production. Linoleic acid (4.5-5.0%, w/w) which is a major fatty acid present ...

Background: Acute appendicitis is the most common surgical emergency of the childhood. Its diagnosis is really challenging. A constellation of through history taking, physical examination, radiographic investigations, and laboratory analysis should be used to balance the risk of delayed operative intervention against the removal of a normal appendix. Here a case with misdiagnosis of acute app...