Abstract Background Genomic instability is a hallmark of various cancers, and DNA repair an essential process for maintaining genomic integrity. Mammalian cells have developed mechanisms in response to damage. Compared the cellular damage, vivo damage (DDR) specific tissues has not been studied extensively. Objective In this study, mice were exposed whole-body gamma (γ)-irradiation evaluate DDR...

Radiation may affect essential functions and behaviors such as locomotion, feeding, learning and memory. Although whole-body irradiation has been shown to reduce motility in the nematode Caenorhabditis elegans, the detailed mechanism responsible for this effect remains unknown. Targeted irradiation of the nerve ring responsible for sensory integration and information processing would allow us t...

background: total body irradiation (tbi) is different from standard radiotherapy in many aspects, so it is not easy to predict the delivered dose to the patient under tbi treatment. diode dosimetry procedures for surface dose reading can help to define variations of the actually delivered dose from the prescribed one. the aim of this study was to describe the measurements made to calibrate diod...

PURPOSE To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. MATERIALS AND METHODS Non-obese diabetic (NOD)-H2(h4) mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB/c mice develop anti-thyrotropin receptor (TSHR) antibodies ...

The mean life span of animals killed by a specific type of tumor is influenced by competing risks. The parametric inference method of Noda et al. was applied to a set of mouse experimental data in order to correct for the appearance of observed life span distribution under competing risks and to test statistical significances of difference between corrected mean life spans. Data were from an ex...

Innate attack to Schistosoma mansoni cercariae was evaluated in irradiated mice. It was observed that 70% of the larvae from mice sacrificed one day after whole body irradiation with 400 or 800 rads were surrounded by cluster reactivities, without difference from controls. Differences were apparent on day 5 after irradiation with sub lethal (400 rads) or lethal doses (800 rads) suggesting that ...