OBJECTIVE The combined contribution of neonatal, perinatal, and maternal health, demographic, environmental, and family psychosocial factors to early onset asthma and wheezing in a healthy birth cohort was examined. METHODS Participants included 1,158 ethnically and socioeconomically diverse parents of 2- and 3-year olds who completed mailed questionnaires. RESULTS Asthma and wheezing preva...

If one excludes cough from the acoustic signs related to respiratory disease, wheezing becomes the most common adventitious lung sound. The whistling tones of wheezing are understood to originate from airway wall flutter when flow becomes limited during airway obstruction.1 It is well recognized that “not all that wheezes is asthma,” but wheezing is most typically heard in patients with asthma....

OBJECTIVE To perform a review of the epidemiological aspects of investigating and treating wheezing in infants. SOURCES A search was run on MEDLINE using the keywords "wheezing," "infants," "diagnosis," "treatment," and "children," and Google was also used to search for "Estudio Internacional de Sibilancias en Lactantes." SUMMARY OF THE FINDINGS The prevalence of wheezing in infants varies ...

OBJECTIVE To evaluate the effect of menarche before 11 years of age on the incidence of wheezing/asthma in girls 11 to 18 years of age. METHODS The study sample comprised 1,350 girls from a birth cohort that started in 1993 in the urban area of the city of Pelotas, southern Brazil; this cohort was followed until 18 years of age. We assessed wheezing by the question, "Have you ever had wheezin...

To the Editor: The prospective trial of dexamethasone for bronchiolitis in infants, conducted by the Bronchiolitis Study Group of the Pediatric Emergency Care Applied Research Network (PECARN) and reported by Corneli et al. (July 26 issue),1 appears to demonstrate a lack of efficacy of oral dexamethasone in infants with a first episode of wheezing diagnosed as bronchiolitis. Although the author...

Respiratory syncytial virus (RSV) is among the last viruses to cause major, predictable worldwide outbreaks of disease and for which no vaccine or broadly effective antiviral drug is available. Annually in the United States, RSV accounts for ∼125 000 hospitalizations, 2.1 million outpatient visits to a pediatrician’s office or an emergency department, and 250 deaths among children in the first ...

OBJECTIVE To evaluate the association between recurrent wheezing and atopy, the Asthma Predictive Index, exposure to risk factors, and total serum IgE levels as potential factors to predict recurrent wheezing. METHODS A case-control study with infants aged 6-24 months treated at a specialized outpatient clinic from November 2011 to March 2013. Evaluations included sensitivity to inhalant and ...

BACKGROUND Low birth weight (LBW) and environmental tobacco smoke (ETS) exposure are each associated with wheezing in children. This study was designed to examine the combined association of LBW and ETS with wheezing. METHODS A retrospective birth cohort analysis linked with a national survey of allergic disorders among 1,018,031 junior high school students in Taiwan (1995-1996) was analyzed....

The relationship between wheezing or asthma and serum immunoglobulin (Ig)E levels in early life is unclear. The aim of this study was to follow-up the IgE immune response in infants that did, or did not, develop recurrent wheezing during their first year of life. One-hundred and two randomised term neonates were included, in which IgE levels were quantified in cord blood samples, at 3, 6, 9 and...

A cross-sectional study was conducted on dietary patterns and their influence on the occurrence of wheezing and atopic and non-atopic asthma in a sample of 1,168 children and adolescents in Salvador, Bahia State, Brazil. Wheezing and asthma symptoms in the previous 12 months were obtained using the ISAAC questionnaire. The presence of aeroallergen-specific IgE was identified. A food frequency q...