The apical ectodermal ridge (AER), a thickening of the limb epithelium at its distal tip, is pivotal for maintaining vertebrate limb outgrowth. In a recent study, Flrt3 has been involved in the activation of ERK by FGFs. Moreover, Flrt3 has been described as a transmembrane protein able to interact with FGF receptors modulating, this way, FGFR signaling, either directly or recruiting cytoplasmi...

During healing of a skin wound, cells that are normally dormant must turn on hundreds of genes in order to proliferate, migrate, and repair the defect. The Polycomb family of proteins epigenetically silence target genes and so downregulation of their expression is a potential mechanism for unsilencing repair genes. Quantitative RT-PCR, western blotting, and immunostaining of invitro epithelial ...

Little is known about the respective contributions of cell proliferation and cell death to the control of vertebrate forebrain growth. The homeodomain containing gene barhl2 is expressed in the diencephalon of Xenopus, zebrafish, and mouse embryos, and we previously showed that its over-expression in Xenopus neuroepithelial cells induces Caspase3-dependent apoptosis. These findings suggested th...

obesity is one of the health threatening problems and the second preventable mortality factor, the prevalence of which is increasing. the economic burden of obesity is estimated at 2-7% of the total healthcare costs and it is predicted to be top health problem of the world in 2025. therefore, following up obesity and developing effective clinical interventions is a significant measure taken in ...

Abstract Background/Aims National and international recommendations for the management of axial spondyloarthritis state importance providing exercise advice. Furthermore, NHS digital plan highlights need virtual consultations, which was supported by patients’ preferences in our Trust. With a focus on self-management conjunction with ‘Aspiring to Excellence' programme, we explored optimal way di...