'The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects. Through consumption of contaminated cereals and cereal products, human and pigs are exposed to this mycotoxin. Using in vitro, ex vivo and in vivo appro...

[1] Storm event patterns of dissolved organic nitrogen (DON) were studied for multiple events across four catchments (1.6–696 ha) in a forested, glaciated watershed in western New York State. Highest concentrations of DON in the watershed were recorded for litter leachate followed by throughfall. Storm event concentrations of DON consistently peaked at or before peak discharge while dissolved o...

Co-occurrence of deoxynivalenol (DON) with other DON derivatives/metabolites and other Fusarium toxins, including zearalenone, nivalenol and as well as other mycotoxins (e.g. fumonisins) is frequently observed in food and feed. DON-3beta-glucopyranoside (DON-3-glucoside) was described as detoxification product of DON in wheat. This mycotoxin conjugate was observed in maize, barley, malt, beer a...

As Director of the Office of Scientific Research and Development, Dr. Vannevar Bush has coordinated the activities of some six thousand leading American scientists in the application of science to warfare. In this significant article he holds up an incentive for scientists when the fighting has ceased. He urges that men of science should then turn to the massive task of making more accessible o...

Previous research showed that nursery pigs fed deoxynivalenol (DON) contaminated diets supplemented with spray-dried porcine plasma (SDPP) had similar growth rate and feed intake as those consuming noncontaminated diets. In this study, two blocks of 100 weanling pigs were used to determine the optimal inclusion level of spray-dried bovine plasma(SDBP) required in nursery diets contaminated with...

Two experiments were conducted to evaluate potential detoxifying agents on growth of nursery pigs fed deoxynivalenol (DON)-contaminated diets. Naturally DON-contaminated wheat (6 mg/kg) was used to achieve desired DON levels. In a 21-d study, 238 pigs (13.4 ± 1.8 kg BW) were used in a completely randomized design with a 2 × 2 + 1 factorial arrangement. Diets were: 1) Positive control (PC; < 0.5...

We report the identification of deoxynivalenol-3-sulfate and deoxynivalenol-15-sulfate as two novel metabolites of the trichothecene mycotoxin deoxynivalenol in wheat. Wheat ears which were either artificially infected with Fusarium graminearum or directly treated with the major Fusarium toxin deoxynivalenol (DON) were sampled 96 h after treatment. Reference standards, which have been chemicall...

Mycotoxins can reduce fertility and development in livestock, notably in pigs and poultry, although the effect of most mycotoxins on reproductive function in cattle has not been established. One major mycotoxin, deoxynivalenol (DON), not only targets immune cells and activates the ribotoxic stress response (RSR) involving MAPK activation, but also inhibits oocyte maturation in pigs. In this stu...

Mycotoxins pose an important danger to human and animal health. Poultry feeds are frequently contaminated with deoxynivalenol (DON) mycotoxin. It is thus of great importance to evaluate the effects of DON on the welfare related parameters in poultry industry. In the present study, the effects of contamination of broiler diet with 10 mg DON/kg feed on plasma corticosterone and heterophil to lymp...