OBJECTIVES Imiquimod is an immune response modifier that has demonstrated a good efficacy and relatively low recurrence rates in comparison to other genital wart treatment modalities. The primary objective of this open-label study was to evaluate the effect on sustained clearance of treated lesions and the safety of patient-applied topical imiquimod after laser therapy of external anogenital wa...

The recent report by Bivins (1) on the successful cultivation of the wart agent on the chorioallantoic membrane (CAM) of embryonated hen's eggs and the report by Strauss, Bunting and Melnick (2) on the electron microscopy of elementary virus bodies in wart tissue prompted the undertaking of similar and extended experiments in this laboratory. Felsher (3) had ground up 3 warts in saline and had ...

INTRODUCTION Cryotherapy with liquid nitrogen is an effective, safe and convenient form of treatment for plantar warts. EMLA® cream (eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is a topical local anaesthetic agent that has proven to be effective and well tolerated in the relief of pain associated with various minor interventions in numerous clinical settings. MATERIALS AND METHODS...

Acral melanoma is a great pretender; anything but i nfrequently, it adopts clinical faces, simulating skin conditions that make the healthcare provider diagnose it as a benign disease of the palms, soles, and ungual regions. We present a case of a hyperkeratotic acral melanoma that has been misdiagnosed and that has led to an amputation of the thumb.

Carcinoma cuniculatum is a rare low-grade well-differentiated squamous cell carcinoma, located mainly on lower limb and essentially on the plantar region (89%). It is the prerogative of the older male. Its pathogenesis remains unknown. Clinical features are suggestive of carcinoma cuniculatum, but histological confirmation often requires multiple deep biopsies namely histological examination of...

The association between the expression of HLA-DR antigens on cervical epithelium and the local immune state of activation in colposcopically obtained biopsy specimens from patients with histologically documented wart virus infection was investigated. In normal cervical epithelium no HLA-DR staining was detected. No or few IL-2R positive cells were found in the contiguous sections. HLA-DR was ex...

Papillomavirus DNA has been reported recently in the vapor (smoke plume) derived from warts treated with carbon dioxide laser; this raises concerns for operator safety. We therefore have studied a group of human and bovine warts to define further the potential risk of wart therapy and to test whether a surgical mask could reduce exposure. Half of each wart was treated with carbon dioxide laser ...

Abnormalities in the migration of cortical neurons to ectopic sites can be caused by prenatal exposure to ethanol. In extreme cases, cells migrate past the pial surface and form suprapial heterotopias or 'warts'. We used organotypic slice cultures from 17-day-old rat fetuses to examine structural and molecular changes that accompany wart formation. Cultures were exposed to ethanol (0, 200, 400 ...

BACKGROUND Seasonal variation has been demonstrated in many diseases, including certain skin diseases. OBJECTIVE To determine whether there is seasonal variation in dermatologic office visits in the USA. METHODS Data on dermatologic office visits were obtained from representative visits to outpatient physicians in the USA from the National Ambulatory Medical Care Survey from 1990 to 1998. O...