The “lead user construct” was developed to preferentially identify commercially attractive innovation-related information developed by users of products and services. In this empirical study of user modifications to Apache web server software, we further develop and test lead user theory by studying the independent and combined effects of two key component variables. We find that one component ...

lar genetic mechanisms. Nephrol Dial Transplant 1996;11 Suppl 6:34–7. (10) Thoenes W, Storkel S, Rumpelt HJ, Moll R. Cytomorphological typing of renal cell carcinoma—a new approach. Eur Urol 1990;18 (Suppl 2):6–9. (11) Gnarra JR, Duan DR, Weng Y, Humphrey JS, Chen DY, Lee S, et al. Molecular cloning of the von Hippel–Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys ...

BACKGROUND Congenital secondary erythrocytoses are due to deregulation of hypoxia inducible factor resulting in overproduction of erythropoietin. The most common germline mutation identified in the hypoxia signaling pathway is the Arginine 200-Tryptophan mutant of the von Hippel-Lindau tumor suppressor gene, resulting in Chuvash polycythemia. This mutant displays a weak deficiency in hypoxia in...

BACKGROUND von Hippel-Lindau disease is a dominantly inherited multi-system syndrome with neoplastic hallmarks. Pancreatic lesions associated with von Hippel-Lindau include serous cystic neoplasms, simple cysts, and neuroendocrine tumors. The combination of pancreatic neuroendocrine tumors and serous cystic neoplasms is relatively rare, and the surgical treatment of these lesions must consider ...

Seven new cases of pregnancy combined with von Willebrand's disease have been reported. Altogether the patients had 11 deliveries, and one abortion after 10 weeks' gestation. The diagnosis was based on the determination of the bleeding time, factor VIII coagulant activity (VIII C), factor VIII-related antigen (VIII RAg) and the ristocetin cofactor (VIII RCoF). Two of our 6 parturients showed pr...