Here, we analyze the viral divergence among HCV chronic cases infected with genotype 25 1. The intrahost viral evolution was assessed by deep sequencing using the 454 Genome 26 Sequencer platform. The results showed a rapid nucleotide sequence divergence. This notorious 27 short-term viral evolution is of the utmost importance for the study of HCV transmission because 28 direct links between re...

A new algorithm for inferring the evolution of within-host viral sequences is presented. A sequential-linking approach is developed so that a longitudinal phylogenetic tree can be reconstructed from sequential molecular data that are obtained at different time points from the same host. The algorithm employs a codon-based model, which uses a Markov process to describe substitutions between codo...

we created a simple cellular automata (ca) model for hepatitis b infection dynamics associated with spatial structure performed under various ages of liver tissue correspond to different immune responses in order to study the effect of spatial heterogeneities on the dynamical evolution of a viral infection. the results of the simulations show biphasic nature of viral load decreases, as observed...

Why some viruses are enveloped while others lack an outer lipid bilayer is a major question in viral evolution but one that has received relatively little attention. The viral envelope serves several functions, including protecting the RNA or DNA molecule(s), evading recognition by the immune system, and facilitating virus entry. Despite these commonalities, viral envelopes come in a wide varie...

We evaluated the predictive value of baseline HIV-1 genotypic resistance mutations for failure of a nucleoside reverse transcriptase inhibitor (NRTI) containing therapy. The change in therapy of 88 HIV-1-infected patients was analyzed retrospectively, relating the genotypic resistance profile at baseline to the evolution of viral load and CD4+ T cell counts. Genotypic resistance at baseline and...