OBJECTIVE Zanjani viper (Vipera albicornuta) is an endemic venomous snake in East Azerbai- jan Province, Iran which is medically important due to its application for antivenin production in the laboratory. We need to produce this snake in captivity. This study was conducted to charac- terize mature male Zanjani viper and to evaluate its sperm reproductive parameters. MATERIALS AND METHODS Thi...

Snakebite envenomation is an uncommon condition in the northern hemisphere, but requires high vigilance with regard to both the systemic effects of the venom and the locoregional impact on the soft tissues. Bites from the adder, Vipera Berus, may have serious clinical consequences due to systemic effects. A case of a 44-year-old man is reported. The patient was bitten in the right hand. He deve...

Background Cancer is one of the major health problems worldwide. Hence, finding potent therapeutics from natural sources seems necessary. Snake venom of Vipera lebetina contains potential component with anticancer activities such as antiproliferation, migration, invasion, adhesion, and angiogenesis effect. Evaluation of cytotoxic and antiadhesive effect of V. lebetina venom on lung epithelial c...

H EMORRHAGE is the outstanding phenomenon observed following the bite by snakes of the Viperidae and Crotalidae families. Subjects bitten by these snakes show local hemorrhage near the site of the bite, slowly extending proximally, and, after death, widespread hemorrhage in many internal organs. In the explanation of the hemorrhage, two mechanisms have been invoked; damage to the vessel wall ca...

H EMORRHAGE is the outstanding phenomenon observed following the bite by snakes of the Viperidae and Crotalidae families. Subjects bitten by these snakes show local hemorrhage near the site of the bite, slowly extending proximally, and, after death, widespread hemorrhage in many internal organs. In the explanation of the hemorrhage, two mechanisms have been invoked; damage to the vessel wall ca...

Nucleotide sequences of mitochondrial cytochrome b and 16S rRNA genes, totaling 946 bp, were used to reconstruct a molecular phylogeny of 42 species of the subfamily Viperinae representing 12 of the 13 recognized genera. Maximum-parsimony and maximum-likelihood were used as methods for phylogeny reconstruction with and without a posteriori weighting. When representatives of the Causinae were ta...

Snakebite remains a neglected medical problem of the developing world with up to 125,000 deaths each year despite more than a century of calls to improve snakebite prevention and care. An estimated 75% of fatalities from snakebite occur outside the hospital setting. Because phospholipase A2 (PLA2) activity is an important component of venom toxicity, we sought candidate PLA2 inhibitors by direc...

Aim. In this study we focused on the search of fibrinogen-targeted proteases in venom Vipera lebetina. Methods. Fractionation was performed using FPLC chromatographic system Acta Prime Q Sepharose. Analysis protein mixtures SDS-PAGE. Аction blood coagulation analyzed APTT assay [2]. Proteolytic action fibrinogen and identification components with fibrinolytic activity electrophoresis mixture so...