PURPOSE The design and development of synthetic small molecules to disrupt microtubule dynamics is an attractive therapeutic strategy for anticancer drug discovery research. Loss of clinical efficacy of many useful drugs due to drug resistance in tumor cells seems to be a major hurdle in this endeavor. Thus, a search for new chemical entities that bind tubulin, but neither are a substrate of ef...

This paper presents methods for analyzing and manipulating unevenly spaced time series without a transformation to equally spaced data. Processing and analyzing such data in its unaltered form avoids the biases and information loss caused by resampling. Care is taken to develop a framework consistent with a traditional analysis of equally spaced data, as in Brockwell and Davis (1991), Hamilton ...

A significant volume of research demonstrates that out-of-school learning activities enhance student development in terms of cognitive, affective and social outcomes. However, there is also evidence that the opportunity to engage in these activities has been severely reduced in recent years. This paper explores the extent to which the provision of such opportunities is unevenly distributed— spa...

A simplified grape carbon balance model, called VitiSim, was adapted from the simplified apple carbon balance model developed earlier. The model uses a daily time step, a big-leaf daily canopy photosynthesis light response and respiration of organs based on mass and specific respiration rates. Weather inputs are only daily max and min temperatures and radiation. Partitioning is based on the bal...

High copper (Cu) levels in uprooted old vineyard soils may cause toxicity in transplanted young vines, although such toxicity may be reduced by inoculating plants with arbuscular mycorrhizal fungi (AMF). The objective of this study was to evaluate the effects of AMF on the plant growth, chlorophyll contents, mycorrhizal colonization, and Cu and phosphorus (P) absorption in young vines cultivate...

Vascular occlusions are common structural modifications made by many plant species in response to pathogen infection. However, the functional role(s) of occlusions in host plant disease resistance/susceptibility remains controversial. This study focuses on vascular occlusions that form in stem secondary xylem of grapevines (Vitis vinifera) infected with Pierce's disease (PD) and the impact of o...

We present the first unbiased molecular line survey towards an extragalac-tic source, namely the nuclear region of the starburst galaxy NGC 253. The scan covers the frequency band from 129.1 to 175.2 GHz, i.e. most of the 2 mm atmospheric window. We identify 111 spectral features as transitions from 25 different molecular species. Eight of which (three tentatively) are detected for the first ti...

Talk 1 (18.10.2017 – Gesina Schwalbe): Overview of some classical results. Recall the classical theorems of Freudenthal and Hurewicz and some elementary calculations of homotopy groups of spheres. Recall the definition of the stable homotopy groups of spheres and explain the ring structure. Show that the Hopf maps are stably essential, i.e. not stably null-homotopic, using Steenrod operations. ...

We provide a nonparametric method for the computation of instantaneous multivariate volatility for continuous semi-martingales, which is based on Fourier analysis. The co-volatility is reconstructed as a stochastic function of time by establishing a connection between the Fourier transform of the prices process and the Fourier transform of the co-volatility process. A nonparametric estimator is...

The effects of three levels of organic matter removal (OMR) and three levels of soil compaction (SC) on the development of understory vegetation in a central hardwood forest were evaluated 9 years after treatments were applied as part of a national program of long-term soil productivity research. The three levels of biomass removal (OMR) were removal of merchantable boles only (OM0), removal of...