tumor size seems to be a determinant in the prognosis of early cervical cancer. patients with tumor size greater than 4 cm (bulky) in diameter have worse outcome.' the purpose of this study was to compare the efficacy of preoperative combined chemoradiation and neoadjuvant chemotherapy (narc) programs followed by radical hysterectomy in stage ib - lib bulky cervical cancer. from september ...

I read with great interest the paper published by Weidmann et al. Their paper is a phase II study in cases ‡80 years with aggressive lymphoma treated by bendamustine plus rituximab (BR) [1]. Majority of these cases (11 of 14) had diffuse large B-cell lymphoma (DLBCL). When we looked at the efficacy of this regimen, complete response (CR) and partial response (PR) were reported in 54% and 15% of...

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating infection of the central nervous system caused by the JC papovavirus usually seen among immunocompromised patients. PML arises upon JC virus reactivation during periods of immunosuppression. PML may be seen among patients with lymphoproliferative disorders and immunosuppression induced by chemotherapy. Recently, an associa...

Primary Mediastinal B-cell Lymphoma (PMBL) is a specific subtype of B-cell lymphoma which shares some phenotypic and genotypic features with diffuse large B-cell lymphoma (DLBCL) and with classical Hodgkin’s lymphoma (HL). The genomic landscape of PMBL has not been fully elucidated, but has revealed the recurrent alteration of genes involved in JAK-STAT signaling and in immune surveillance [1]....

The genetic hallmark of mantle cell lymphoma (MCL) is the translocation t(11;14)(q13;q32), which occurs in more than 95% of the cases. It juxtaposes the cyclin D1 encoding gene CCND1/BCL1/PRAD-1 on 11q13 and the immunoglobulin heavy chain (IGH) gene located on 14q32 [1]. It results in overexpression of the cyclin D1 protein that drives the transition from G1 to S phase of cell cycle. However, t...

The use of drugeluting stents (DES) has tackled the "Achilles' heel" of percutaneous coronary interventions (PCI) like no innovation before: the restenosis following initially successful PCI of de novo stenoses. Today, with DES, the pivotal clinical parameter TVF (target vessel failure) is in the upper single- digit range for "standard" lesions and 16% for long lesions. Numerous studies have as...

Hodgkin's lymphoma (NHL) are malignant lymphoproliferative diseases arising from a mutant lymphoid cell. Follicular lymphoma is the most common indolent (low-grade) NHL. No cure approach (watch and wait) is recommended for low-grade lymphomas without Bsymptoms. Mono-therapy with chlorambucil or cyclophosphamid is prescribed in case of disease progression. In NHL of high malignancy, especially w...

Primär kutane Lymphome sind extranodale T- oder B-Zell-Non-Hodgkin-Lymphome, die vorwiegend ältere Patienten betreffen, aber in allen Altersgruppen einschließlich der ersten Lebensjahre auftreten können. Die Diagnose kutaner ist eine Herausforderung und erfordert einen hohen klinischen Verdacht sowie enge Zusammenarbeit zwischen Dermatologen, pädiatrischen Onkologen Pathologen. Generell müssen ...