نتایج جستجو برای: vinca variegata
تعداد نتایج: 1597 فیلتر نتایج به سال:
BACKGROUND Several clinical trials have performed risk-benefit analyses comparing docetaxel and pemetrexed or docetaxel and vinca alkaloid, but the efficacy and safety remain uncertain. The aim was to conduct a meta-analysis to compare the efficacy and safety of docetaxel and pemetrexed or docetaxel and vinca alkaloid for non-small-cell lung cancer. METHODS This meta-analysis of Phase III ran...
(1) Intraguild predation (IGP) can occur among aphidophagous predators thus reducing their effectiveness in controlling crop pests. Among ladybirds, Coccinella septempunctata L. and Hippodamia variegata Goeze are the most effective predators upon Aphis gossypii Glov., which is an economically important pest of melon. Understanding their likelihood to engage in reciprocal predation is a key poin...
\Ve have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by means of their effects on mitotic spindle microtubules or by another mechanism or by a combination of mechanisms. Five Vìnca alkaloids were used to investigate the relationship in Urla cells between inhibition of cell proliferation and blockage of mitosis, alteration o...
Chemotherapy-induced peripheral neurotoxicity is a major problem because it represents the dose-limiting side effect of a significant number of antineoplastic drugs, such as vinca alkaloids. Hereditary neuropathies usually predispose to severe vincristine neurotoxicity. Here, we report the case of a 56-year-old man with Machado-Joseph disease, also known as spinocerebellar ataxia type 3, treate...
During a phase I trial of EC145 (a folate-targeted vinca alkaloid conjugate), constipation was identified as the dose-limiting toxicity, probably from a nonfolate receptor-related liver clearance process capable of releasing unconjugated vinca alkaloid from EC145 and shuttling it to the bile. Here, we report on the selective placement of novel carbohydrate segments (1-amino-1-deoxy-glucitolyl-γ...
On direct comparison by TLC and IR we established that the alkaloids A-5 and A-4, first isolated from Vinca herbacea W. K . 1 are identical to the oxindole alkaloid majdine (I), later isolated from Vinca major L. 2' 3 and with its isomer isomajdine (II), prepared by heating of (I) in acetic anhydride 2. Based upon some spectroscopic evidence it was claimed2, that majdine was a diastereomer of c...
The use of spawning sites by Bombina variegata was analysed in a dynamic habitat containing a variety of different ponds. Cool or shadowy as well as permanent ponds were not used for spawning at all. Among the ephemeral ponds that were used, egg numbers increased with water temperature, both when compared among ponds and between different areas within ponds. Egg numbers were also higher in pond...
Indole ahloids of Vinca species are valued greatly in medical sciences, one reason being for their use as powerful anticancer agents. There are four species of Vinca in Iran: V. rosea, V. major, V. minor and V. herbacea. In previous investigations, we found that these plants have considerable alkaloid similarity (58.8- 75%). Therefore, chromosomic and electrophuretic studies followed after i...
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